Kirigami-Inspired Stretchable Piezoelectret Sensor for Analysis and Assessment of Parkinson's Tremor.

Human muscle activity contains rich information that can reflect human movement patterns and conditions of diseases or physical abnormalities. Flexible pressure sensors enable the assessment of muscle tremors in Parkinson's disease (PD) through Force Myography (FMG). Here, an easily fabricated, ultra-sensitive, and stretchable piezoelectret pressure sensor is presented. Utilizing an effective integration of Kirigami structure and piezoelectret air gap, the sensor achieved a dynamic sensitivity of ≈725 pC/N (@5 Hz), measurement repeatability of <2.5%, measurement hysteresis of <1%, a pressure detection limit of <15 Pa, a response time of ≈2.5 ms, stable output within ±3% over 40 000 cycles, and output decay of <2.5% after 1000 cycles of complex deformation, meeting non-distorted measurement conditions up to 20 Hz. Successful monitoring and assessment of hand muscle tremors are demonstrated. Furthermore, using a 1×3 sensor array enabled tremor localization, achieving a high accuracy rate of 99.5% with machine learning algorithms. Additionally, the sensor facilitated the experimental quantification and assisted scoring of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), with an accuracy of ≈85%. The sensor demonstrates potential for assisting in the diagnosis and rehabilitation monitoring of Parkinson's disease.