Evidence map›Paper›PMID 39578105›Full record

ArticleAJNR. American journal of neuroradiology2025

The Cortical Vein Opacification Score (COVES) Is Independently Associated with DSA ASITN Collateral Score.

Dhairya A Lakhani, Aneri B Balar, Subtain Ali, Musharaf Khan, Hamza Salim, Manisha Koneru, Sijin Wen, Richard Wang, Janet Mei, Argye E Hillis and 8 more

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In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Dhairya A LakhaniFrom the Department of Radiology and Radiological Sciences (D.A.L., A.B.B., H.S., R.W., J.M., V.S.Y.), Johns Hopkins University, Baltimore, Maryland dhairyalakhani@gmail.com.ORCID 0000-0001-7577-1887
Aneri B BalarFrom the Department of Radiology and Radiological Sciences (D.A.L., A.B.B., H.S., R.W., J.M., V.S.Y.), Johns Hopkins University, Baltimore, Maryland.
Subtain AliDepartment of Neuroradiology (D.A.L., S.A., M. Khan, A.T.R.), West Virginia University, Morgantown, West Virginia.ORCID 0000-0002-9522-9881
Musharaf KhanDepartment of Neuroradiology (D.A.L., S.A., M. Khan, A.T.R.), West Virginia University, Morgantown, West Virginia.
Hamza SalimFrom the Department of Radiology and Radiological Sciences (D.A.L., A.B.B., H.S., R.W., J.M., V.S.Y.), Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-5208-8425
Manisha KoneruCooper Medical School of Rowan University (M. Koneru), Camden, New Jersey.
Sijin WenDepartment of Biostatistics (S.W.), West Virginia University, Morgantown, West Virginia.
Richard WangFrom the Department of Radiology and Radiological Sciences (D.A.L., A.B.B., H.S., R.W., J.M., V.S.Y.), Johns Hopkins University, Baltimore, Maryland.
Janet MeiFrom the Department of Radiology and Radiological Sciences (D.A.L., A.B.B., H.S., R.W., J.M., V.S.Y.), Johns Hopkins University, Baltimore, Maryland.
Argye E HillisDepartment of Neurology (A.E.H.), Johns Hopkins University, Baltimore, Maryland.
Jeremy J HeitDepartment of Neurology (J.J.H., G.W.A.), Stanford University, Stanford, California.ORCID 0000-0003-1055-8000
Greg W AlbersDepartment of Neurology (J.J.H., G.W.A.), Stanford University, Stanford, California.
Adam A DmytriwDepartment of Radiology (A.A.D.), Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-0131-5699
Tobias D FaizyDepartment of Radiology (T.D.F.), Neuroendovascular Division, University Medical Center Münster, Münster, Germany.
Max WintermarkDepartment of Neuroradiology (M.W.), MD Anderson Medical Center, Houston, Texas.ORCID 0000-0002-6726-3951
Kambiz NaelDivision of Neuroradiology (K.N.), Department of Radiology, University of California San Francisco, San Francisco, California.ORCID 0000-0002-4194-9488
Ansaar T RaiDepartment of Neuroradiology (D.A.L., S.A., M. Khan, A.T.R.), West Virginia University, Morgantown, West Virginia.ORCID 0000-0001-9864-4805
Vivek S YedavalliFrom the Department of Radiology and Radiological Sciences (D.A.L., A.B.B., H.S., R.W., J.M., V.S.Y.), Johns Hopkins University, Baltimore, Maryland.

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

background and purposePretreatment CTA-based Cortical Vein Opacification Score (COVES) has been shown to predict good functional outcomes at 90 days in patients with acute ischemic stroke secondary to large vessel occlusion (AIS-LVO). This is thought to be related to its ability to measure collateral status (CS). However, its association with the reference standard test, the DSA-based American Society of Interventional and Therapeutic Neuroradiology (ASITN) collateral score, has yet to be established. Therefore, this study assesses the relationship between COVES and ASITN CS. MATERIALS AND

methodsIn this prospectively collected, retrospectively reviewed analysis, patients with anterior circulation LVO from September 1, 2017, to October 1, 2023, were included. The COVES grading, which ranges from 0 to 6, was independently assessed by 2 board-certified neuroradiologists. The ASITN CS was independently assessed by a board-certified neuroradiologist and the performing neurointerventionalist. Any discrepancies were resolved through consensus review. Spearman rank correlation, univariable logistic regression, multivariable logistic regression, and receiver operating characteristic curve analysis were performed. A

resultsIn total, 311 consecutive patients (median, IQR = 68 years [59-78 years]; 55.9% women) met our inclusion criteria. There was significant positive correlation between COVES and ASITN CS (ρ = 0.41,

conclusionsBy demonstrating the independent association of COVES with the reference standard test for collateral status assessment, the ASITN CS, we further validate the role of COVES in estimating collateral status.

Indexed as

Angiography, Digital SubtractionCerebral AngiographyCerebral VeinsCollateral CirculationComputed Tomography AngiographyIschemic StrokeAgedFemaleHumansMaleMiddle AgedRetrospective Studies

Identifiers

PMID39578105
PMCPMC12091969

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.