ArticleAJNR. American journal of neuroradiology2025
Hyperperfusion and Blood-Brain Barrier Disruption beyond the Diffusion-Restricted Infarct 1 Day after Successful Mechanical Thrombectomy.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Blood Flow Restriction Training in Stroke Rehabilitation: A Narrative Review of Current Evidence and Future Directions.Brain and behavior · 2026Review
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposePatterns of the cerebral microcirculatory response with changes in the BBB and perfusion in patients with stroke and a large vessel occlusion are still unclear. We combined dynamic contrast-enhanced (DCE) permeability and DSC perfusion MRI to detect such patterns beyond the borders of the diffusion-restricted infarct core after successful recanalization. MATERIALS AND
methodsCombined DCE permeability and DSC perfusion MRI were performed prospectively in patients within 24 hours after successful mechanical recanalization of acute MCA occlusion. Perfusion alterations were visually assessed on CBF and CBV maps; blood-brain barrier disruptions (BBBD), on
resultsThirty-eight patients were included in the study. Subtle hyperperfusion beyond the DWI lesion was present in 13/38 patients (34%) on CBF-maps; and elevated CBV, in 15/38 patients (39%). In these patients, the ratios between ipsi- and contralateral white matter CBF (
conclusionsCombined DCE permeability and DSC perfusion imaging is feasible in patients 24 hours after successful thrombectomy and reveals subtle hyperperfusion and BBBD occurring frequently beyond the diffusion-restricted infarct core.
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