Evidence map›Paper›PMID 39578031›Full record

ArticleBMJ open2024

Association between triglyceride-glucose index and risk of kidney stone: a Chinese population-based case-control study.

Dawei Wang, Dingguo Zhang, Lin Zhang, Feng Shi, Yu Zhu

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Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dawei Wang *Department of Urology, Ruijin Hospital, Shanghai, China.ORCID http://orcid.org/0000-0003-3063-0874
Dingguo Zhang *Department of Urology, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Lin ZhangThe School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-2064-8440
Feng Shi *CAAC East China Aviation Personnel Medical Appraisal Center, Civil Aviation Shanghai Hospital, Shanghai, China.
Yu Zhu *Department of Urology, Ruijin Hospital, Shanghai, China zy10478@rjh.com.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the association between the triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance and the risk of kidney stones (KSs) in a Chinese population.

designCase-control study.

settingThree Physical Examination Centers in Shanghai, China, between January 2020 and December 2022.

participantsA total of 117 757 Chinese adults underwent health check-ups during the study period. PRIMARY AND SECONDARY OUTCOME MEASURES: The association between the TyG index and the risk of KS was assessed using multivariable logistic regression analysis. The dose-response relationship between the TyG index and KS risk was evaluated with a restricted cubic spline (RCS) analysis. Stratified analyses were conducted to explore whether factors such as age, sex, obesity, hypertension and diabetes modify the association between the TyG index and KS risk.

resultsOut Of the 117 757 participants, 11 645 (9.9%) were diagnosed with KS using ultrasound. Individuals with KS had significantly higher TyG values than controls (p<0.001). The multivariable-adjusted ORs for KS increased across TyG quartiles, with the highest quartile showing an OR of 1.28 (95% CI 1.20 to 1.36) compared with the lowest quartile. Each SD increase in the TyG index was associated with a 10% higher risk of KS (OR: 1.10, 95% CI 1.08 to 1.13). RCS analysis revealed a significant positive and linear association between TyG index and KS (p overall<0.001, p non-linear=0.136). The positive association persisted across the subgroup and sensitivity analyses.

conclusionsThe TyG index was positively associated with the risk of prevalent KS, suggesting that insulin resistance may be a risk factor for KS in the Chinese population.

Indexed as

Blood GlucoseInsulin ResistanceKidney CalculiTriglyceridesAdultAgedBiomarkersCase-Control StudiesChinaEast Asian PeopleFemaleHumansLogistic ModelsMaleMiddle AgedRisk FactorsBiomarkersBlood GlucoseTriglyceridesCase-Control StudiesDiabetes & endocrinologyLipid disordersUrolithiasis

Identifiers

PMID39578031
PMCPMC11590796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.