ArticleThe American journal of clinical nutrition2025
Infant body composition trajectories differ by in utero exposure to gestational diabetes mellitus: a prospective cohort from birth to 12 months.
Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Breastfeeding Intensity and Duration and Growth Trajectories in GDM Exposed Infants: The SWIFT Study.Pediatric obesity · 2026Article
- Birth-size reference charts for newborns admitted to the neonatal intensive care units.BMC pediatrics · 2026Article
- Hyperglycemia during the first 1000 days as a driver of metabolic programming.Frontiers in endocrinology · 2026Review
- Prenatal exposure to hyperglycemia and child growth trajectories in the first 3 years of life: a prospective birth cohort.BMC medicine · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundInfants exposed to gestational diabetes mellitus (GDM) in utero are known to have higher fat mass (FM) and less fat-free mass (FFM) at birth, but little is known about how their adiposity changes over the first year of life.
objectivesWe identified growth and body composition patterns across the first year and evaluated for differences by GDM exposure status.
methodsAmong 198 infants (52% GDM exposed), growth and body composition with total body electrical conductivity were obtained from birth to 1 y. Latent class mixed modeling (LCMM) trajectories were fit for weight-, length-, and body mass index (BMI)-for-age World Health Organization z-scores, as well as percent body fat, FM, and FFM. Adjusted associations between GDM with trajectory classes were evaluated with multiple logistic regression.
resultsAt birth, infants exposed to GDM had higher FM, higher percent body fat, and a higher BMI compared with infants unexposed. A larger proportion of infants exposed to GDM were classified into LCMM growth trajectory classes that experienced less FM (67% GDM exposed) and percent body fat gain (79% GDM exposed), compared with the other classes (Χ
conclusionsIn a cohort of infants exposed and unexposed to GDM in utero, infants exposed had increased weight, FM, and percent body fat at birth. However, more infants exposed to GDM had less fat accrual over the first year of life, compared with those unexposed. The long-term effects of these growth patterns in the first year challenge current concepts and support further investigation of neonatal body composition.
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