Evidence map›Paper›PMID 39577796›Full record

ArticleMolecular and cellular endocrinology2025

Luteal fibroblasts produce prostaglandins in response to IL1β in a MAPK-mediated manner.

Corrine F Monaco, Chloe M Jones, Harlan R Sayles, Brooke Rudloff, Renee McFee, Andrea S Cupp, John S Davis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Corrine F MonacoDepartment of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE, USA; Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
Chloe M JonesDepartment of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE, USA.
Harlan R SaylesDepartment of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.
Brooke RudloffDepartment of Animal Science, University of Nebraska-Lincoln, Lincoln, NE, USA.
Renee McFeeDepartment of Animal Science, University of Nebraska-Lincoln, Lincoln, NE, USA.
Andrea S CuppDepartment of Animal Science, University of Nebraska-Lincoln, Lincoln, NE, USA.
John S DavisDepartment of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE, USA; US Department of Veterans Affairs VA Medical Center, Omaha, NE, USA. Electronic address: jsdavis@unmc.edu.

Funding

The Aging Pituitary/Gonadal AxisP01AG029531 · NIA · WICHITA STATE UNIVERSITY · PI GEORGE R BOUSFIELD · 2009 to 2026
$25.9M
Metabolic Regulators of Corpus Luteum FunctionR01HD092263 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DAVIS, JOHN S · 2017 to 2021
$1.6M
Metabolic Events Controlling Ovarian SteroidogenesisR01HD087402 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DAVIS, JOHN S · 2017 to 2019
$425k
Vascular remodeling in the ovaryR03HD112585 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DAVIS, JOHN S · 2023 to 2023
$154k
BLRD VA I01 BX004272BLRD VA IK6 BX005797NIA NIH HHS P01 AG029531NICHD NIH HHS R01 HD087402NICHD NIH HHS R01 HD092263NICHD NIH HHS R03 HD112585
6 · The paper itself

Abstract

The corpus luteum is a temporary endocrine gland that is crucial for pregnancy, as it produces the progesterone needed to maintain optimal uterine conditions for implantation. In the absence of a conceptus, the corpus luteum becomes non-functional and undergoes rapid tissue remodeling to regress into a fibrotic corpus albicans. Early luteal regression is characterized by increased cytokine release. Because the role of fibroblasts in the bovine corpus luteum remains to be elucidated, the aim of this study was to elucidate the response of bovine luteal fibroblasts to inflammatory cytokines, tumor necrosis factor α (TNFα), and interleukin 1β (IL1β). Both cytokines induced canonical mitogen activated protein kinase (MAPK) signaling in luteal fibroblasts by phosphorylation of ERK1/2, p38 MAPK, and JNK. IL1β elevated expression and phosphorylation of cytosolic phospholipase A2 (cPLA

Indexed as

FibroblastsInterleukin-1betaMAP Kinase Signaling SystemProstaglandinsAnimalsCattleCells, CulturedCorpus LuteumCyclooxygenase 2DinoprostoneFemalePhospholipases A2, CytosolicPhosphorylationTumor Necrosis Factor-alphaCyclooxygenase 2DinoprostoneInterleukin-1betaPhospholipases A2, CytosolicProstaglandinsTumor Necrosis Factor-alphaCorpus luteumCytokineFibroblastInterleukinMicroenvironmentProstaglandinsTumor necrosis factor

Identifiers

PMID39577796
PMCPMC12782534

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.