Evidence map›Paper›PMID 39577760›Full record

Trial reportThe Journal of pediatrics2025

Chorioamnionitis and Two-Year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy.

Marie-Coralie Cornet, Fernando F Gonzalez, Hannah C Glass, Tai-Wei Wu, Jessica L Wisnowski, Yi Li, Patrick Heagerty, Sandra E Juul, Yvonne W Wu

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Infection and neonatal encephalopathy.Pediatric research · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marie-Coralie CornetDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA. Electronic address: Marie-Coralie.Cornet@ucsf.edu.
Fernando F GonzalezDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA.
Hannah C GlassDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA; Department of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA.
Tai-Wei WuDivision of Neonatology, Department of Pediatrics, Fetal Neonatal Institute, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA.
Jessica L WisnowskiDepartment of Pediatrics, Children's Hospital Los Angeles and the Keck School of Medicine, University of Southern California, Los Angeles, CA.
Yi LiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.
Patrick HeagertyDepartment Biostatistics, University of Washington, Seattle, WA.
Sandra E JuulDepartment of Pediatrics, University of Washington School of Medicine, Seattle, WA.
Yvonne W WuDivision of Neonatology, Department of Pediatrics, Fetal Neonatal Institute, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA.

Funding

High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) CCCU01NS092764 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JUUL, SANDRA E, WU, YVONNE W · 2016 to 2020
$12.7M
Maternal Chorioamnionitis and Hypoxic-Ischemic Encephalopathy: The MATCH StudyK23HD109684 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Marie Cornet · 2022 to 2026
$867k
Validating MRS lipids as biomarkers of brain injury in neonates with hypoxic-ischemic encephalopathyK23HD099309 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WISNOWSKI, JESSICA L · 2019 to 2023
$693k
NICHD NIH HHS K23 HD099309NICHD NIH HHS K23 HD109684NINDS NIH HHS U01 NS092764
6 · The paper itself

Abstract

objectiveTo determine if chorioamnionitis is associated with an increased risk of adverse 2-year outcomes among infants with hypoxic-ischemic encephalopathy (HIE). STUDY

designThis cohort study included all infants with moderate to severe HIE treated with therapeutic hypothermia and enrolled on the High-dose Erythropoietin for Asphyxia and Encephalopathy Trial. Clinical chorioamnionitis (CC) was defined as a diagnosis made by a treating obstetrician and histologic chorioamnionitis (HC) was defined as placental inflammation observed on histology. We used proportional odds regression to determine the associations between CC, HC, and an ordinal 2-year neurodevelopmental outcome measure: no neurodevelopmental impairment (NDI), mild NDI, moderate NDI, severe NDI, or death.

resultsOf 500 infants, 65 (13%) were exposed to CC. Of 317 infants with placental data available, 125 (39%) were exposed to HC. Infants exposed to CC (odds ratio 0.57, 95% CI 0.34-0.95) and those exposed to HC (odds ratio 0.62, 95% CI 0.40-0.96) had a lower severity of primary outcome than unexposed infants. Infants exposed to chorioamnionitis also had lower frequencies of sentinel events (CC: P = .001; HC: P = .005), central pattern magnetic resonance imaging brain injury (CC: P = .02; HC: P = .02), and electroencephalogram background abnormalities (CC: P = .046; HC: P = .02), compared with unexposed infants.

conclusionsInfants with HIE who were exposed to chorioamnionitis had lower severity of 2-year outcomes than unexposed infants. Our findings suggest that chorioamnionitis may lead to a lower severity of brain dysfunction than other pathophysiologic mechanisms of encephalopathy.

Indexed as

ChorioamnionitisHypoxia-Ischemia, BrainCohort StudiesErythropoietinFemaleFollow-Up StudiesHumansHypothermia, InducedInfantInfant, NewbornMalePregnancyErythropoietinbrainbrain injurychorioamnionitiselectroencephalographyhypothermiahypoxia-ischemiainducedinfantinflammationlaborneurodevelopmentplacentapregnancy

Identifiers

PMID39577760
PMCPMC12136926

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.