ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2024
EEG aperiodic dynamics from early through late childhood: Associations with ADHD, cognition, and development.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Inattention in Pediatric Attention-Deficit/Hyperactivity Disorder and Anxiety: Neurophysiological Evidence for Distinct and Overlapping Cognitive Mechanisms.Journal of attention disorders · 2026Article
- Firemaster 550 differentially alters gene expression underlying synaptic function in amygdala of prairie voles after gestational or lactational exposure.Neurotoxicology · 2026Article
- Atypical auditory cortical processing in ADHD during early and middle childhood.Developmental cognitive neuroscience · 2026Article
- Reliable but Wrong? Automated Detection of Heart Rate Artifacts as a Source of Bias in Pediatric EEG Data.Research square · 2026Article
- The developmental shift in aperiodic activity and its link to the default mode network in attention-deficit hyperactivity disorder.Psychological medicine · 2026Article
- EEG-based frontal excitation/inhibition balance as an objective biomarker for cognitive fatigue across multiple sclerosis and Long COVID.Psychological medicine · 2026Article
- Exploring neurodevelopment through oscillatory and aperiodic EEG activity: methodological and clinical consideration.Frontiers in human neuroscience · 2025Review
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7 authors.
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Abstract
backgroundAperiodic resting electroencephalography (EEG) activity is dynamic, reflecting shifting excitatory:inhibitory (E:I) balance with changing environmental conditions. We examined developmental and cognitive correlates of aperiodic and dynamic aperiodic indices in a cross-sequential cohort of early, middle, and late childhood youth with and without attention deficit hyperactivity disorder (ADHD).
methodsTwo-hundred eighty-five children ages 2 - 14 years provided resting EEG during high- and low-visual input conditions. Licensed clinical psychologists determined ADHD diagnosis or likelihood (in young children). Linear regressions were estimated to examine associations between aperiodic features and age, ADHD diagnosis, IQ, and experimental condition.
resultsFrom early to middle childhood, the aperiodic exponent increased linearly, indicating lower E:I, followed by a decreasing trajectory in late childhood. The aperiodic exponent was greater with high versus low visual input in young children, but this effect reversed with age. The ADHD group had a decreased aperiodic exponent, overall. Dynamic aperiodic activity, i.e. shifts in E:I balance, was associated with IQ.
conclusionsThe aperiodic exponent and aperiodic dynamics are proxies for age-related cortical maturation and E:I balance, and have distinct associations with ADHD symptoms and cognitive ability. SIGNIFICANCE: We provide novel evidence that dynamic aperiodic activity is a candidate marker of cortical efficiency in childhood.
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