Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Robert LoughnanDepartment of Cognitive Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0003-4870-4501
Jonathan AhernDepartment of Cognitive Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Mary BoyleDepartment of Cognitive Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0002-1662-6820
Terry L JerniganDepartment of Cognitive Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0002-2011-9370
Donald J HaglerCenter for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.
John R IversenCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92161, USA.ORCID 0000-0002-4172-9848
Oleksandr FreiNORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-6427-2625
Diana M SmithCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92161, USA.ORCID 0000-0002-7484-0980
Ole AndreassenNORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-4461-3568
Noah ZaitlenDepartment of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-3553-3670
Leo SugrueDepartment of Radiology and Biomedical Imaging and Department of Psychiatry, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA.ORCID 0000-0001-7315-4519
Wesley K ThompsonCenter for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK 74103, USA.ORCID 0000-0002-1148-1976
Anders DaleDepartment of Cognitive Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0002-6126-2966
Andrew J SchorkInstitute of Biological Psychiatry, Mental Health Center-Sct Hans, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0003-4164-9335
Chun Chieh FanCenter for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.ORCID 0000-0001-9437-2128
Funding
OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Healthy Brain and Child Development National Consortium Data Coordinating CenterU24DA055330 · NIDA · WASHINGTON UNIVERSITY · PI ANDERS M DALE, Damien A Fair · 2021 to 2026
$34.6M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescentsR01MH128959 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Fiona C Baker, Chun Chieh Fan · 2022 to 2026
$3.9M
Identifying and quantifying genetic effects on neurodevelopmental trajectories in adolescentsR01MH122688 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FAN, CHUN CHIEH · 2020 to 2024
$1.8M
Data Exploration and Analysis Portal for Brain Research through Advanced Imaging NeuroscienceRF1MH120025 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FAN, CHUN CHIEH, THOMPSON, WESLEY KURT · 2020 to 2020
$1.1M
Large-scale nested studies of the impact of music on brain and behavioral developmentR01AA028411 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IVERSEN, JOHN REHNER · 2019 to 2021
Our understanding of brain iron regulation and its disruption in disease is limited. Excess iron affects motor circuitry, contributing to Parkinson's disease (PD) risk. The molecular mechanisms regulating central iron levels, beyond a few well-known genes controlling peripheral iron, remain unclear. We generated scores based on the archetypal brain iron accumulation observed in magnetic resonance imaging scans of individuals with excessive dietary iron absorption and hemochromatosis risk. Genome-wide analysis revealed that this score is highly heritable, identifying loci associated with iron homeostasis, and driven by peripheral iron levels. Our score predicted gait abnormalities and showed a U-shaped relationship with PD risk, identifying individuals with threefold increased risk. These results establish a hormetic relationship between brain iron and PD risk, where central iron levels are strongly determined by genetics via peripheral iron. This framework combining forward and reverse genetics is a powerful study design to understand genomic drivers underlying high dimensional phenotypes.
Indexed as
BrainGenome-Wide Association StudyHemochromatosisIronMagnetic Resonance ImagingParkinson DiseaseFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedIron
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Hemochromatosis neural archetype reveals iron disruption in motor circuits. · full record | OpenQuestion