Evidence map›Paper›PMID 39576856›Full record

ArticleScience advances2024

CalDAG-GEFI acts as a guanine nucleotide exchange factor for LRRK2 to regulate LRRK2 function and neurodegeneration.

Qinfang Liu, Bingxu Huang, Noah Guy Lewis Guiberson, Shifan Chen, Dong Zhu, Gang Ma, Xin-Ming Ma, Jill R Crittenden, Jianzhong Yu, Ann M Graybiel and 3 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qinfang LiuDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.ORCID 0000-0003-2930-3892
Bingxu HuangDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
Noah Guy Lewis GuibersonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Shifan ChenDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
Dong ZhuDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.ORCID 0009-0008-2741-7160
Gang MaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Xin-Ming MaDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
Jill R CrittendenMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jianzhong YuDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-4883-646X
Ann M GraybielMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-4326-7720
Ted M DawsonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-6459-0893
Valina L DawsonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2915-3970
Yulan XiongDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.ORCID 0000-0003-1649-7552

Funding

Understanding Mechanisms of a-synuclein pathologyP50NS038377 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ROSENTHAL, LIANA ISA SHAPIRO · 1998 to 2019
$38.8M
Functional and anatomical characterization of the striosomal systemR01MH060379 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Ann M Graybiel · 2000 to 2026
$8.7M
Molecular Regulation of LRRK2 in Parkinson's DiseaseR01NS112506 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI XIONG, YULAN · 2020 to 2024
$1.8M
Upstream regulation of the Hippo signaling pathwayR01GM136904 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI YU, JIANZHONG · 2020 to 2024
$1.7M
The role of aging in LRRK2-associated Parkinsons diseaseK01AG046366 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI XIONG, YULAN · 2014 to 2018
$647k
NIA NIH HHS K01 AG046366NIGMS NIH HHS R01 GM136904NIMH NIH HHS R01 MH060379NINDS NIH HHS P50 NS038377NINDS NIH HHS R01 NS112506
6 · The paper itself

Abstract

Mutations in

Indexed as

Guanine Nucleotide Exchange FactorsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2AnimalsDisease Models, AnimalDrosophilaHEK293 CellsHumansMiceMutationParkinson DiseaseProtein BindingGuanine Nucleotide Exchange FactorsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, human

Identifiers

PMID39576856
PMCPMC11584015

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.