Evidence map›Paper›PMID 39576763›Full record

ReviewPLoS pathogens2024

Eimeria: Navigating complex intestinal ecosystems.

Shengjie Weng, Erjie Tian, Meng Gao, Siyu Zhang, Guodong Yang, Bianhua Zhou

Abstract readReview
In one paragraph

Review in PLoS pathogens, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shengjie WengCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China.
Erjie TianCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China.
Meng GaoCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China.
Siyu ZhangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China.
Guodong YangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China.
Bianhua ZhouCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China.ORCID 0000-0003-3811-3898

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eimeria is an intracellular obligate apicomplexan parasite that parasitizes the intestinal epithelial cells of livestock and poultry, exhibiting strong host and tissue tropism. Parasite-host interactions involve complex networks and vary as the parasites develop in the host. However, understanding the underlying mechanisms remains a challenge. Acknowledging the lack of studies on Eimeria invasion mechanism, we described the possible invasion process through comparative analysis with other apicomplexan parasites and explored the fact that parasite-host interactions serve as a prerequisite for successful recognition, penetration of the intestinal mechanical barrier, and completion of the invasion. Although it is recognized that microbiota can enhance the host immune capacity to resist Eimeria invasion, changes in the microenvironment can, in turn, contribute to Eimeria invasion and may be associated with reduced immune capacity. We also discuss the immune evasion strategies of Eimeria, emphasizing that the host employs sophisticated immune regulatory mechanisms to suppress immune evasion by parasites, thereby sustaining a balanced immune response. This review aims to deepen our understanding of Eimeria-host interactions, providing a theoretical basis for the study of the pathogenicity of Eimeria and the development of novel anticoccidial drugs.

Indexed as

CoccidiosisEimeriaHost-Parasite InteractionsAnimalsEcosystemHumansImmune EvasionIntestinal MucosaIntestines

Identifiers

PMID39576763
PMCPMC11584145

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.