ArticleMolecular biotechnology2025
Association Between the Expression of T Helper Type 17 Cell-Related Cytokines and Valve Damage in Rheumatic Heart Disease.
Article in Molecular biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Valve biology and rheumatic heart disease pathogenesis.Nature cardiovascular research · 2026Review
- Chronic Mitral Valve Fibrosis in Rheumatic Heart Disease: From Immune Trigger to Inflammatory and Mechanical Progression.Journal of the American Heart Association · 2025Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aimed to clarify the association between Th17 cell-related cytokine expressions and valve damage in rheumatic heart disease (RHD). Twenty RHD patients undergoing mitral valve replacement surgery were selected as the observation group (Group O), and 20 non-rheumatic valve disease patients undergoing mitral valve replacement surgery (degenerative mitral valve prolapse) were recruited as the control group (Group C). Histopathological examination with hematoxylin and eosin (H&E) staining was conducted to observe inflammatory cell infiltration, fibrosis, and neovascularization. Immunohistochemical staining was performed to analyze Th17 cell-related cytokines (interleukin (IL)-17, IL-6, IL-23, IL-21) in patients' cardiac valve tissues. Spearman correlation analysis was employed to investigate the correlation between Th17-related cytokines and inflammatory cell infiltration, fibrosis, and neovascularization. compared to the Group C, the Group O exhibited significantly higher proportions of IL-17, IL-21, IL-6, and IL-23 positive cells and immunohistochemical scores in valve tissues (P < 0.05). Additionally, inflammatory cell infiltration scores, tissue fibrosis scores, and neovascularization scores in valve tissues were significantly higher in the Group O compared to the Group C (P < 0.05). The expression of Th17-related cytokines IL-17, IL-21, IL-6, and IL-23 in valve tissues showed a positive correlation with inflammatory cell infiltration, fibrosis, and neovascularization (P < 0.05). Conclusion: The results demonstrate a notable association between Th17 cell-related cytokine expressions in the heart valves of RHD patients and valve damage, providing a potential target for the treatment and prevention of RHD.
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Registered trials
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