Evidence map›Paper›PMID 39576267›Full record

ArticleRNA biology2024

A high-throughput search for intracellular factors that affect RNA folding identifies

Alejandra Matsuri Rojano-Nisimura, Lucas G Miller, Aparna Anantharaman, Aaron T Middleton, Elroi Kibret, Sung H Jung, Rick Russell, Lydia M Contreras

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The evolution of a NaJournal of bacteriology · 2026
    Article
  2. The evolution of a NabioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alejandra Matsuri Rojano-NisimuraDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.ORCID 0009-0006-7539-590X
Lucas G MillerMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.ORCID 0009-0008-0575-6030
Aparna AnantharamanMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Aaron T MiddletonDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Elroi KibretDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Sung H JungDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Rick RussellDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Lydia M ContrerasMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0001-5010-5511

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Mechanisms and Specificity of Proteins that Manipulate DNA and RNA StructureR35GM131777 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Rick Russell · 2019 to 2026
$3.2M
Novel mechanisms of posttranscriptional regulation by CsrAR01GM135495 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI CONTRERAS, LYDIA MARIA · 2020 to 2024
$1.8M
NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R01 GM135495NIGMS NIH HHS R35 GM131777
6 · The paper itself

Abstract

General RNA chaperones are RNA-binding proteins (RBPs) that interact transiently and non-specifically with RNA substrates and assist in their folding into their native state. In bacteria, these chaperones impact both coding and non-coding RNAs and are particularly important for large, structured RNAs which are prone to becoming kinetically trapped in misfolded states. Currently, due to the limited number of well-characterized examples and the lack of a consensus structural or sequence motif, it is difficult to identify general RNA chaperones in bacteria. Here, we adapted a previously published

Indexed as

Escherichia coliEscherichia coli ProteinsMolecular ChaperonesRNA-Binding ProteinsRNA FoldingHigh-Throughput Screening AssaysNucleic Acid ConformationProtein BindingRNA, BacterialRNA, CatalyticEscherichia coli ProteinsMolecular ChaperonesRNA, BacterialRNA-Binding ProteinsRNA, Catalyticnucleic acid binding proteinsprotein-RNA interactionsRNA-bindingRNA chaperonesRNA folding

Identifiers

PMID39576267
PMCPMC11587861

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.