ArticleEpilepsia2025
Structural connectivity changes in focal epilepsy: Beyond the epileptogenic zone.
Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Quantitative dual-tracerEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Thalamo-Lesional Connectivity Signatures of Bilateral Tonic-Clonic Seizures in Focal Cortical Dysplasia-Related Epilepsy.Annals of clinical and translational neurology · 2026Article
- Integrating multisequence radiomics and clinical features to predict seizure recurrence after gross total resection of pediatric low-grade epilepsy-associated brain tumors.Neuroradiology · 2026Article
- Pursuit of biomarkers of brain diseases: beyond cohort comparisons.NPJ digital medicine · 2026Review
- Advances in Thalamic Neuromodulation for Epilepsy: From Mechanisms to Clinical Translation.Epilepsy currents · 2026Article
- Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: From operating room to wet lab.Epilepsia open · 2026Article
- Multimodal Imaging in Epilepsy Surgery for Personalized Neurosurgical Planning.Journal of personalized medicine · 2025Review
- Structural and effective brain connectivity in focal epilepsy.Neuroimage. Reports · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
objectiveEpilepsy is recognized increasingly as a network disease, with changes extending beyond the epileptogenic zone (EZ). However, more studies of structural connectivity are needed to better understand the behavior and nature of this condition.
methodsIn this study, we applied differential tractography, a novel technique that measures changes in anisotropic diffusion, to assess widespread structural connectivity alterations in a total of 42 patients diagnosed with medically refractory epilepsy (MRE), including 27 patients with focal epilepsy and 15 patients with multifocal epilepsy that were included to validate our hypothesis. All patients were compared individually to an averaged database constructed from 19 normal controls regressed by age and sex.
resultsStatistical analyses revealed specific distribution patterns of tracts with increased connectivity that were located in multiple subcortical structures across all patients including the arcuate fasciculus, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, uncinate fasciculus, fornix, and short U fibers. Conversely, pathways with a significant decrease in connectivity (p < .05) exhibited a more central distribution near mesial structures across all patients (corpus callosum, cingulum, corticospinal tract, and sensory fibers). SIGNIFICANCE: Our findings add to the growing evidence that focal epilepsy is not solely anatomically confined, but is rather a network disorder that extends beyond the EZ, and differential tractography shows strong potential as a clinical biomarker for assessing structural connectivity alterations in patients with epilepsy.
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