Evidence map›Paper›PMID 39576068›Full record

ArticlemBio2025

Jeffrey R Strich, Marcos J Ramos-Benitez, Seth Warner, Heather Kendall, Sydney Stein, Andrew P Platt, Sabrina C Ramelli, Shelly J Curran, Izabella Lach, Kiana Allen and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Breaking the Stalemate: Advancing Sepsis Therapeutics Beyond Supportive Care.Public health reports (Washington, D.C. : 1974) · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jeffrey R StrichCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-5671-1130
Marcos J Ramos-BenitezCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Seth WarnerCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Heather KendallComparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Sydney SteinCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Andrew P PlattCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Sabrina C RamelliCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Shelly J CurranCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Izabella LachCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Kiana AllenCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Ashley BabyakCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Luis J Perez-ValenciaCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Mahnaz MinaiComparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Junfeng SunCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Kevin M VannellaCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Derron AlvesComparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Richard HerbertComparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Daniel S ChertowCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-1675-1728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonhuman primate models that closely emulate the disease course, pathogenesis, and supportive care provided to human patients in the modern intensive care unit with bacterial sepsis are urgently needed to study pathogenesis and assess novel therapies. We therefore developed a non-human primate model of septic shock that includes supportive care akin to a modern intensive care unit. In this study, we characterized pathogen kinetics and evaluated the physiologic, immunologic, and pathologic responses in this model of septic shock induced by the clinically relevant pathogen

Indexed as

Disease Models, AnimalKlebsiella InfectionsKlebsiella pneumoniaeShock, SepticAnimalsBacteremiaBlood Coagulation DisordersCritical CareCytokinesEndotoxinsMaleMultiple Organ FailureCytokinesEndotoxinsnonhuman primatepathogenesissepsistherapeutics

Identifiers

PMID39576068
PMCPMC11708033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.