ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Midlife and late-life environmental exposures on dementia risk in the Wisconsin Longitudinal Study: The modifying effects of ApoE.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Multidimensional workplace stressors differentially impact cognitive trajectories.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Identification of chemicals targeting dementia genes and pathways in the Comparative Toxicogenomics Database.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neighborhood Socioeconomic Deprivation is Associated with Worse Cognitive Performance and in vivo Amyloid Accumulation.Research square · 2026Article
- Neighborhood socioeconomic deprivation is associated with worse cognitive performance and in vivo amyloid accumulation.NPJ dementia · 2026Article
- Identification of chemicals targeting dementia genes and pathways in the Comparative Toxicogenomics Database.bioRxiv : the preprint server for biology · 2025Article
- Association of Early Life Risk Factors and APOE ε4 With Incident Dementia: Evidence From 14 Years of U.S. Data.Journal of the American Geriatrics Society · 2025Article
- Dementia prevalence in the Wisconsin Longitudinal Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Long-term exposure to air pollution and gastrointestinal disease: findings from a nationwide cohort study in China.BMC public health · 2025Article
- Midlife and late-life environmental exposures on dementia risk in the Wisconsin Longitudinal Study: The modifying effects of ApoE.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Interconnected pathways: Social determinants of health, infections, and Alzheimer's disease and related dementias.Alzheimer's & dementia (New York, N. Y.)Article
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6 authors.
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Abstract
introductionLate-life air pollution exposure is associated with an increased risk for dementia, with this effect exacerbated among apolipoprotein E-4 (ApoE-4) carriers. However, whether midlife occupational exposures likewise influence dementia outcomes, and varies as a function of ApoE-4 status is unknown.
methodsUsing data from 3814 participants in the Wisconsin Longitudinal Study (WLS), we employed weighted logistic regression to evaluate associations between midlife occupational respiratory exposures and late-life air pollution on all-cause dementia risk, stratified by ApoE-4 status.
resultsMidlife occupational exposure was associated with increased odds of all-cause dementia preferentially among ApoE-4 noncarriers (odds ratio [OR] = 1.59, p = 0.01), whereas higher late-life urban air pollution exposure was associated with increased dementia risk among ApoE-4 carriers (OR = 1.258, p = 0.029). DISCUSSION: Associations between environmental exposures and dementia risk vary based on the timing of exposure and ApoE-4 status. While late-life environmental exposures are associated with dementia among ApoE-4 carriers, for noncarriers midlife environmental exposure confers the greatest risk. HIGHLIGHTS: The effect of adult environmental respiratory exposures on subsequent dementia risk varies as a function of both ApoE-4 carrier status and exposure timing. Midlife occupational exposure to respiratory hazards is preferentially associated with increased dementia odds among ApoE-4 noncarriers. Late-life exposure to ambient air pollution is associated with dementia risk, but only among ApoE-4 carriers. While higher exposure to PM
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