ArticleThe Plant cell2024
KNUCKLES regulates floral meristem termination by controlling auxin distribution and cytokinin activity.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Insights into Candidate Pathways Associated with Multi-Pistil Formation in Chinese Chestnut (Biology · 2026Article
- Characterization of BrSTM16 from Brassica rapa and functional analysis of its role in regulating cold tolerance.BMC plant biology · 2026Article
- Phytohormones and Shoot Branching: A Mini-Review of Molecular Regulatory Networks and Mechanisms.Plants (Basel, Switzerland) · 2026Review
- Article
- Brassinosteroid signaling regulates shoot apical meristem homeostasis via orchestrating cytokinin and WUSCHEL activity.Science advances · 2026Article
- Physiological and Transcriptomic Dissection of Inflorescence Degeneration inPlants (Basel, Switzerland) · 2026Article
- Integrated multi-omics and WGCNA analyses reveal pathways and candidate genes associated with branching flower development in Nymphaea prolifera: focusing on hormone homeostasis and flavonoid biosynthesis.BMC plant biology · 2026Article
- WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Article
- Comparative Transcriptomics Analysis Reveals Genes Associated with a Dehiscent-Corolla Mutant in Sesame (International journal of molecular sciences · 2025Article
- Fluctuations in nitrate availability impact cytokinin biosynthesis through histone modifications of IPT3 in Arabidopsis roots for growth acclimation.Plant communications · 2025Article
- The Role of CRABS CLAW Transcription Factor in Floral Organ Development in Plants.International journal of molecular sciences · 2025Review
- Histone acetyltransferase GCN5 orchestrates flower development and is required for proper regulation of multiple key meristem and organ identity genes.The Plant cell · 2025Article
- IAA-Mediated Haustorium Formation inPlants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification ofPlants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2025Article
- Meristem fate: to terminate, or not?Frontiers in plant science · 2025Review
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3 authors.
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Abstract
The termination of floral meristem (FM) activity is essential for the normal development of reproductive floral organs. During this process, KNUCKLES (KNU), a C2H2-type zinc finger protein, crucially regulates FM termination by directly repressing the expression of both the stem cell identity gene WUSCHEL (WUS) and the stem cell marker gene CLAVATA3 (CLV3) to abolish the WUS-CLV3 feedback loop required for FM maintenance. In addition, phytohormones auxin and cytokinin are involved in FM regulation. However, whether KNU modulates auxin and cytokinin activities for FM determinacy control remains unclear. Here, we show that the auxin distribution and the cytokinin activity mediated by KNU in Arabidopsis (Arabidopsis thaliana) promote the termination of FM during stage 6 of flower development. Mutation of KNU leads to altered distribution of auxin and cytokinin in the FM of a stage 6 floral bud. Moreover, KNU directly represses the auxin transporter gene PIN-FORMED1 (PIN1) and the cytokinin biosynthesis gene ISOPENTENYLTRANSFERASE7 (IPT7) via mediating H3K27me3 deposition on these 2 loci to regulate auxin and cytokinin activities. Our study presents a molecular regulatory network that elucidates how the transcriptional repressor KNU integrates and modulates the activities of auxin and cytokinin, thus securing the timed FM termination.
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