ArticleJournal of diabetes investigation2025
Association between severity of diabetic complications and risk of cancer in middle-aged patients with type 2 diabetes.
Article in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Microvascular Complications and Cancer Risk in Type 2 Diabetes: A Population-Based Study.Cancers · 2025Article
- Letter to the Editor in Response to "Association between severity of diabetic complications and risk of cancer in middle-aged patients with type 2 diabetes".Journal of diabetes investigation · 2025Article
- Response to the comment of Wasti on "Association between severity of diabetic complications and risk of cancer in middle-aged patients with type 2 diabetes".Journal of diabetes investigation · 2025Article
- Impact of China's National Volume-Based Procurement policy exclusively for insulin on the volume, expenditure and price: an interrupted time series analysis in Guangdong Province.Frontiers in public health · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
aimHyperglycemia was found to be associated with an increased risk of cancer in a general population cohort. However, it remains to be established whether the severity of diabetic complications is associated with cancer risk in patients with diabetes. MATERIALS AND
methodsWe used the National Health Insurance Research Database from 2000 through 2013, including those with newly diagnosed diabetic patients (n = 616,742). We collected all vascular and metabolic complications to develop an adapted diabetic complication severity index (aDCSI), ranging from 0 to 13 annually, as proxies of the severity of diabetic complications and performed follow-up from the onset of diabetes until incident cancer, death, or the study end.
resultsWithin the mean follow-up period of 9 years, the rates of cancer incidence per 100,000 person-years were 815.2 vs 482.0 and 611.1 vs 358.9 for the top vs bottom quartiles, respectively, of aDCSI in men and women (adjusted HRs 1.17 (95% CI 1.10-1.25) and 1.20 (95% CI 1.10-1.30), respectively). The risk of cancer was 1.7- to 1.9-fold for the top vs bottom quartiles of aDCSI in diabetic onset age of 40-44 (HRs 1.74 (95% CI, 1.39-2.18) in men and HRs 1.93 (95% CI, 1.39-2.66) in women). However, among patients with diabetic onset age of 60-64, the associations between the severity of diabetic complications and cancer risk were attenuated.
conclusionsPatients with higher severity of diabetic complications have an increased risk of cancer compared to those with the lowest severity, particularly for those with earlier onset and greater severity of diabetic complications.
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