Evidence map›Paper›PMID 39575755›Full record

ArticleJournal of the American Heart Association2024

HIV-Associated Heart Failure: Phenotypes and Clinical Outcomes in a Safety-Net Setting.

Matthew S Durstenfeld, Anjali Thakkar, Diane Jeon, Robert Short, Yifei Ma, Zian H Tseng, Priscilla Y Hsue

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Echocardiography in HIV Disease.Current cardiology reports · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Matthew S DurstenfeldDivision of Cardiology at ZSFG and Department of Medicine University of California, San Francisco (UCSF) San Francisco CA USA.ORCID 0000-0002-7612-3352
Anjali ThakkarDivision of Cardiology, Department of Medicine University of California, San Francisco San Francisco CA USA.ORCID 0000-0003-2037-4475
Diane JeonDivision of Cardiology, Department of Medicine University of California, San Francisco San Francisco CA USA.
Robert ShortDepartment of Medicine University of California, San Francisco San Francisco CA USA.
Yifei MaDivision of Cardiology at ZSFG and Department of Medicine University of California, San Francisco (UCSF) San Francisco CA USA.
Zian H TsengSection of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine University of California, San Francisco San Francisco CA USA.ORCID 0000-0001-5996-4099
Priscilla Y HsueDivision of Cardiology at ZSFG and Department of Medicine University of California, San Francisco (UCSF) San Francisco CA USA.ORCID 0000-0002-3427-6043

Funding

Cardiac Pathology and Risk Prediction for Sudden Cardiac Death in Patients with HIVR01HL126555 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TSENG, ZIAN H · 2014 to 2017
$3.1M
Role of Hematopoietic System and Proteomics in HIV-Associated CardiovascularDiseaseK24AI112393 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y. · 2014 to 2024
$1.9M
UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC)K12HL143961 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y., HUANG, LAURENCE · 2018 to 2022
$1.8M
Low Cardiorespiratory Fitness and Chronotropic Incompetence inHIV: Risk Factors, Cardiovascular Implications, and Exercise Training as TreatmentK23HL172699 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthew Durstenfeld · 2024 to 2026
$593k
NHLBI NIH HHS K12 HL143961NHLBI NIH HHS K23 HL172699NHLBI NIH HHS R01 HL126555NIAID NIH HHS K24 AI112393
6 · The paper itself

Abstract

backgroundHIV is associated with increased risk of heart failure (HF) but data regarding phenotypes of HF and outcomes after HF diagnosis, especially within the safety net where half of people with HIV in the United States receive care, are less clear. METHODS AND

resultsUsing an electronic health record cohort of all individuals with HF within a municipal safety-net system from 2001 to 2019 linked to the National Death Index Plus, we compared HF phenotypes, all-cause mortality, HF hospitalization, and cause of death for individuals with and without HIV. Among people with HF (n=14 829), 697 individuals had HIV (4.7%). People with HIV were diagnosed with HF 10 years younger on average. A higher proportion of people with HIV had a reduced ejection fraction at diagnosis (37.9% versus 32.7%). Adjusted for age, sex, and risk factors, coronary artery disease on angiography was similar by HIV status. HIV was associated with 55% higher risk of all-cause mortality (hazard ratio [HR], 1.55 [95% CI, 1.37-1.76];

conclusionsAmong people with HF who receive care within a municipal safety-net system, HIV infection is associated with higher mortality, despite lower odds of HF hospitalization, attributable to noncardiovascular causes including substance-related and HIV-related mortality.

Indexed as

Heart FailureHIV InfectionsHospitalizationPhenotypeSafety-net ProvidersAdultAgedCause of DeathElectronic Health RecordsFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsStroke Volumeclinical outcomesheart failureHIVmortality

Identifiers

PMID39575755
PMCPMC11681565

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.