Evidence map›Paper›PMID 39575715›Full record

ArticleJournal of the American Heart Association2024

Racial and Ethnic Disparities in the Use and Outcomes With WATCHMAN FLX: A SURPASS Analysis of the NCDR Left Atrial Appendage Occlusion Registry.

Oluseun O Alli, Jalaj Garg, Brian C Boursiquot, Samir R Kapadia, Robert W Yeh, Matthew J Price, Jonathan P Piccini, Devi G Nair, Jonathan C Hsu, Douglas N Gibson and 4 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Oluseun O AlliDivision of Cardiology Novant Health Heart and Vascular Institute Charlotte NC USA.ORCID 0009-0002-6931-2435
Jalaj GargDivision of Cardiology, Cardiac Arrhythmia Service Loma Linda University Health Loma Linda MN USA.ORCID 0000-0002-6857-7418
Brian C BoursiquotDepartment of Medicine Columbia University Irving Medical Center New York New York NY USA.ORCID 0000-0001-8174-1721
Samir R KapadiaDepartment of Cardiovascular Medicine Heart, Vascular, and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-0026-3391
Robert W YehRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology Beth Israel Deaconess Medical Center Boston MA USA.ORCID 0000-0002-0564-4468
Matthew J PriceDivision of Cardiovascular Diseases Scripps Clinic La Jolla CA USA.ORCID 0000-0002-7892-2430
Jonathan P PicciniDivision of Cardiology Duke University Medical Center Durham NC USA.ORCID 0000-0003-0772-2404
Devi G NairDepartment of Cardiac Electrophysiology St. Bernard's Heart and Vascular Center Jonesboro AK USA.ORCID 0000-0001-8253-947X
Jonathan C HsuCardiac Electrophysiology Section, Division of Cardiology, Department of Medicine University of California San Diego CA USA.ORCID 0000-0002-1523-573X
Douglas N GibsonDivision of Cardiovascular Diseases Scripps Clinic La Jolla CA USA.ORCID 0000-0002-8248-5827
Dominic AlloccoBoston Scientific Corp Marlborough MA USA.ORCID 0000-0002-0577-1555
Thomas ChristenBoston Scientific Corp Marlborough MA USA.
Brad SuttonBoston Scientific Corp Marlborough MA USA.
James V FreemanSection of Cardiovascular Medicine Yale University School of Medicine, New Haven, Connecticut and Center for Outcomes Research and Evaluation, Yale-New Haven Hospital New Haven CT USA.ORCID 0000-0002-4614-6879

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundLeft atrial appendage occlusion (LAAO) is increasingly used as an alternative to oral anticoagulation for stroke prevention in select patients with atrial fibrillation. Data on outcomes in racial and ethnic minority individuals are limited. This analysis assessed differences in the use and outcomes of LAAO by race and ethnicity in a large national registry. METHODS AND

resultsThis analysis acquired data on patients who underwent WATCHMAN FLX implantation from the retrospective NCDR (National Cardiovascular Data Registry) LAAO registry through September 2022. All patients with an attempted WATCHMAN FLX implantation and known race and ethnicity were included. Baseline characteristics and 1-year event rates were compared. A total of 97 185 patients were analyzed; 87 339 were White individuals (90%), 3750 Black individuals (3.9%), and 2866 Hispanic individuals (Hispanic/Latinx), 2.9%). Black and Hispanic patients were younger, with a higher incidence of prior stroke and significant bleeding compared with White patients. Black and Hispanic patients were treated with LAAO in smaller numbers relative to their proportion of the US population. Rates of procedural success were similar between groups. Though direct oral anticoagulants were prescribed in most patients across the groups, dual and single antiplatelet therapy were prescribed more often in Black patients. Black patients had significantly higher rates of 1-year death and bleeding compared with White and Hispanic patients.

conclusionsPatients from racial and ethnic minority groups comprise a disproportionately small fraction of all patients who undergo LAAO. Black and Hispanic patients were younger but had significantly higher comorbidities compared with White patients. Procedural success was similar among the groups, but Black patients experienced higher rates of death and bleeding at 1 year.

Indexed as

Atrial AppendageAtrial FibrillationHealthcare DisparitiesRegistriesStrokeAgedAged, 80 and overAnticoagulantsBlack or African AmericanFemaleHispanic or LatinoHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAnticoagulantsatrial fibrillationbleedingleft atrial appendage occlusionracial disparitystroke

Identifiers

PMID39575715
PMCPMC11681556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.