Evidence map›Paper›PMID 39575710›Full record

ReviewAntioxidants & redox signaling2024

Development of Calcium-Dependent Phospholipase A2 Inhibitors to Target Cellular Senescence and Oxidative Stress in Neurodegenerative Diseases.

Cristelle Hugo, Isaac Asante, Anastasiia Sadybekov, Vsevolod Katritch, Hussein N Yassine

Abstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. APOE-Targeted Therapeutics for Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cristelle HugoDepartment of Neurology, Keck School of Medicine, Los Angeles, California, USA.
Isaac AsanteDepartment of Ophthalmology, Keck School of Medicine, Los Angeles, California, USA.
Anastasiia SadybekovDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, California, USA.
Vsevolod KatritchDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, California, USA.
Hussein N YassineDepartment of Neurology, Keck School of Medicine, Los Angeles, California, USA.ORCID 0000-0002-2483-649X

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
The delivery of essential fatty acids to the Brain in Alzheimer's diseaseR01AG054434 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2017 to 2021
$5.4M
Biomarkers of ABCA1 mediated functions in Alzheimers diseaseR01AG055770 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2017 to 2021
$4.2M
ApoE, ABCA1 and endosomal dysregulation in ADR01AG067063 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2020 to 2024
$3.4M
Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4 Diversity SupplementRF1AG076124 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARVANITAKIS, ZOE, YASSINE, HUSSEIN N · 2022 to 2024
$2.5M
Efficient synthon-based modular screening of Giga-to-Terra-scale virtual librariesR01GM147537 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KATRITCH, VSEVOLOD · 2022 to 2024
$1.2M
Computational approaches to discover ligands with new chemotypes and functional propertiesR35GM153437 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VSEVOLOD KATRITCH · 2024 to 2026
$899k
NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG054434NIA NIH HHS R01 AG055770NIA NIH HHS R01 AG067063NIA NIH HHS RF1 AG076124NIGMS NIH HHS R01 GM147537NIGMS NIH HHS R35 GM153437
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cellular SenescenceNeurodegenerative DiseasesOxidative StressAnimalsHumansPhospholipase A2 InhibitorsPhospholipases A2, CytosolicPhospholipase A2 InhibitorsPhospholipases A2, Cytosoliccalcium-dependent phospholipase A2 (cPLA2)cellular senescenceeicosanoidsinflammationoxidative stresssmall-molecule screening

Identifiers

PMID39575710
PMCPMC12344127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.