ArticleJournal of the American Heart Association2024
Dispersion of Activation in Single-Beat Global Maps During Programmed Ventricular Stimulation Identifies Infarct-Related Ventricular Tachycardia Isthmus Sites.
Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Cardiac Macrophages and Fibroblasts Modulate Atrial Fibrillation Maintenance.Circulation research · 2026Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElectrophysiological characterization of ventricular tachycardia (VT) isthmus sites is complex and time-consuming. We aimed at developing and validating a global mapping strategy during programmed ventricular stimulation (PVS) to reveal the underlying electrophysiological properties of the infarct-related substrate and to enable identification of highly heterogeneous activation sites associated with protected VT isthmus sites. METHODS AND
resultsExperimental study that included 22 pigs with established myocardial infarction undergoing in vivo characterization of the anatomical and functional myocardial substrate associated with potential arrhythmogenicity. High-density sequential activation maps during ventricular pacing and VT were compared with single-beat maps using a 64-pole basket catheter positioned in the left ventricle. Further analyses were performed using a novel local activation time-dispersion score to identify regional activation time heterogeneities on both baseline drive pacing and each of the extrastimuli of the PVS protocol. Basket catheter splines covered a median of 81.2% of the endocardial surface of the left ventricle. Basket-catheter-derived single-beat activation maps (N=16) during pacing showed a linear relationship with high-density sequential activation maps. Induction of ventricular arrhythmias was associated with higher local activation time-dispersion score values on single-beat global maps during PVS (N=6, 46 arrhythmia induction attempts). Single-beat-derived local activation time-dispersion score maps during successive coupled extrastimuli of the PVS showed a progressive increase in the predictive performance to identify monomorphic VT isthmus sites within the scar region (area under the curve = 0.779 in S2, area under the curve = 0.859 in S4; N=7).
conclusionsSixty-four-pole-derived single-beat local activation time-dispersion score global maps during PVS identify infarct-related endocardial regions with highly heterogeneous activation times that are associated with protected VT isthmus sites.
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