ReviewMolecular medicine reports2025
Risk factors and treatment strategies for adjacent segment disease following spinal fusion (Review).
Review in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Paper template-based intraoperative rod bending for percutaneous stabilization of thoracic extension-distraction fracture: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- How to Treat Adjacent-Segment Pathology Following Lumbar Fusion Surgery: Decompression Alone or Decompression With Extended Fusion Surgery?Neurospine · 2026Article
- Efficacy comparison of arthroscopic-assisted uniportal spinal surgery and percutaneous endoscopic discectomy for adjacent segment lumbar disc herniation after fusion surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Efficacy comparison of arthroscopic-assisted uniportal spinal surgery and percutaneous endoscopic discectomy for adjacent segment lumbar disc herniation after fusion surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Potential Applications of Additive Manufacturing in Intervertebral Disc Replacement Using Gyroid Structures with Several Thermoplastic Polyurethane Filaments.Biomedicines · 2026Article
- Utilization of Total Posterior Spine System facet arthroplasty for management of adjacent segment disease following lumbar spinal fusion: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Polyethylene Stresses in Lumbar Total Joint Replacement Under Elevated Loading: Insights from an Anatomic Finite Element Model.Bioengineering (Basel, Switzerland) · 2026Article
- The Biomechanical Landscape of Lumbar Disc Herniation: Mechanobiological Insights Into Injury and Regeneration.Neurospine · 2026Review
- The impact of metabolic syndrome on one-year patient-reported outcomes after lumbar fusion surgery.North American Spine Society journal · 2025Article
- Sulfated chitosan enhances BMP-2-mediated spinal fusion via skeletal stem cell rejuvenation in aging.Bioactive materials · 2025Article
- Long-term outcomes of total lumbar disc prosthesis: Sustained pain relief.North American Spine Society journal · 2025Article
- Giant calcified lumbar disc herniation in post-operative adjacent segment degeneration: a case report.Journal of spine surgery (Hong Kong) · 2025Article
- Article
- Comparison of Endoscopic Unilateral Laminectomy for Bilateral Decompression (Endo-ULBD) and Posterior Lumbar Interbody Fusion (PLIF) in Managing Multi-Segmental Lumbar Spinal Stenosis: Technique and Early Outcomes.Orthopaedic surgery · 2025Article
- Assessment of lumbosacral spinal curvatures before and after surgery using 3D posturography.Scientific reports · 2025Article
- Long-Term Outcomes of Minimally Invasive vs. Traditional Open Spinal Fusion: A Comparative Analysis.Journal of spine research and surgery · 2025Article
- Unilateral biportal endoscopy for the treatment of adjacent segment disease after lumbar fusion in elderly patients: a matched comparison study.Frontiers in surgery · 2025Article
- Interlaminar Endoscopic Treatment of Adjacent Segment Disease After Posterior Instrumented Lumbar Fusion.Journal of pain research · 2025Article
- Scoliosis as a Paradigm of Pathological Spinal Curvature: Molecular Mechanisms and Imaging Innovations : Molecular and Imaging Insights in Scoliosis.Galen medical journal · 2025Review
- Tissue engineering strategies for treating intervertebral disc degeneration.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adjacent segment disease (ASD) is a significant clinical complication following cervical and lumbar spinal fusion surgery, characterized by the degeneration of spinal segments adjacent to the fused area. The present literature review aimed to elucidate the risk factors contributing to ASD and to evaluate current and emerging treatment strategies. Epidemiological data indicate that patient‑related factors such as age, pre‑existing spinal degeneration and comorbidities, along with surgical factors including the type of fusion, instrumentation and alignment correction, play pivotal roles in ASD development. Biomechanical alterations post‑fusion further exacerbate the risk. The underlying mechanisms of ASD involve changes in spinal kinematics and disc degeneration, driven by inflammatory and degenerative processes. Diagnostic modalities, such as magnetic resonance imaging and computed tomography scans, are essential for early detection and accurate diagnosis. Preventive strategies emphasize meticulous preoperative planning, advanced surgical techniques and postoperative rehabilitation. Treatment approaches range from conservative methods such as physical therapy and pharmacological interventions to surgical solutions, including revision surgeries and the use of motion‑preserving technologies. Emerging therapies, particularly in regenerative medicine, show promise in mitigating ASD. The present review underscored the necessity of a multidisciplinary approach to optimize patient outcomes and highlighted the need for ongoing research to address gaps in the current understanding of ASD in both cervical and lumbar regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.