ArticleCase reports in dermatological medicine2024
Treatment of Xylazine-Associated Injection Skin Injuries.
Article in Case reports in dermatological medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Surgical Challenges and Harm-reduction Strategies in Xylazine-associated Wounds: A Systematic Review.Plastic and reconstructive surgery. Global open · 2026Article
- Impact of lab-based drug checking services on syringe service program engagement in Maryland, USA.Harm reduction journal · 2026Article
- Perceptions and Experiences of Xylazine, Disparities in Xylazine Awareness, and Correlates of Xylazine-Attributed Wounds Among People Who Use Opioids.International journal of environmental research and public health · 2026Article
- Amputation trends among people who use drugs in the context of Philadelphia's increasingly xylazine adulterated drug supply.Drug and alcohol dependence · 2025Article
- Multidisciplinary Guidance to Care for Persons With Xylazine-Associated Wounds.Open forum infectious diseases · 2025Review
- Two Cases of Maggot-AssociatedCase reports in infectious diseases · 2024Article
- Development and Validation of an Image-Based Deep Learning Tool for Identification of Xylazine-Associated Wounds.Journal of addiction medicineArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the introduction of fentanyl and xylazine in the drug supply market, injection-related skin injuries and wounds are becoming more common. Xylazine is an alpha-2 adrenergic agonist thought to cause deep ulcerative wounds due to peripheral vasoconstriction leading to poor wound healing. This case series describes four patients with injection drug use leading to severe xylazine-related skin injuries who were treated between 2022 and 2023. This paper provides visualization of the extent and severity of these "tranq wounds," as well as the healing progression when receiving medical treatment, addiction treatment, and wound care. Medical treatment and overall care were complicated by individual social determinants of health. Further understanding of xylazine-related wounds is necessary as xylazine continued to be an emerging threat in the United States. Though some reports in the literature capture the appearances, only few displayed progressive improvements or success in treatment given the challenging nature of treating this high-risk population.
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Registered trials
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