ArticleCureus2024
Management of Saddle Pulmonary Embolism in the Context of Heparin-Induced Thrombocytopenia and Granulomatosis With Polyangiitis.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Heparin-induced thrombocytopenia (HIT) is a serious, immune-mediated complication of heparin therapy that paradoxically increases the risk of thrombosis while causing a significant reduction in platelet count. In this report, we present the case of a 65-year-old Caucasian female with a history of granulomatosis with polyangiitis (GPA) and acute kidney injury requiring dialysis who was admitted with progressive shortness of breath. Imaging confirmed the presence of a saddle pulmonary embolus and multiple segmental emboli, complicated by bilateral pulmonary infarcts. Given her history of HIT, direct thrombin inhibitors (DTIs) were initiated, with argatroban used in conjunction with warfarin. Close monitoring of anticoagulation was performed using activated partial thromboplastin time (APTT) and international normalized ratio (INR) trends. The case highlights the challenges of managing pulmonary embolism (PE) in the context of HIT and GPA, emphasizing the need for multidisciplinary decision-making and individualized anticoagulation strategies.
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