ArticleResearch square2024
Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer's disease.
Andrew K Evans, Heui Hye Park, Claire E Woods, Rachel K Lam, Daniel Ryskamp Rijsketic, Christine Xu, Emily Chu, Peter Ciari, Sarah Blumenfeld, Laura M Vidano and 3 more
Abstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors.
Andrew K EvansStanford University.
Heui Hye ParkStanford University.
Claire E WoodsStanford University.
Rachel K LamStanford University.
Daniel Ryskamp RijsketicStanford University.
Christine XuStanford University.
Emily ChuStanford University.
Peter CiariStanford Universityf.
Sarah BlumenfeldStanford University.
Laura M VidanoStanford University.
Nay L SawStanford University.
Boris D HeifetsStanford University.
Mehrdad ShamlooStanford University.
Funding
Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI MICHAEL KENNEY · 2007 to 2026
$71.4MTraining CoreP50DA042012 · NIDA · STANFORD UNIVERSITY · PI Karl A. Deisseroth · 2017 to 2026
$27.1MA Shared Neuroscience Platform for National Dissemination and Training in Brain Organogenesis, Behavioral and Brain Disease Models, Viral Vectors, and Imaging TechnologiesU24NS124026 · NINDS · STANFORD UNIVERSITY · PI William T Newsome, Sergiu Pasca · 2022 to 2026
$6.5MRole of beta-adrenergic receptors in modulation of cognition and central and peripheral immune systems in Alzheimer's diseaseR01AG054533 · NIA · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2017 to 2021
$2.4MMapping Neural Circuit Activity Mediating MDMA's Prosocial EffectR01MH130591 · NIMH · STANFORD UNIVERSITY · PI Boris Dov Heifets · 2023 to 2026
$2.3MAnimal Research Equipment, Digital Cages & Metabolic, Avoidance, Fear Conditioning, Place Preference, Self-Administration, Open Field, & Microdialysis Systems for Translational NeuroscienceS10OD030452 · OD · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2021 to 2021
$743kRole of beta adrenergic receptors in modulation of cognition, pathology and neuroinflammation in Alzheimer's DiseaseR21NS097945 · NINDS · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2016 to 2017
$443kNCI NIH HHS P30 CA124435NIA NIH HHS R01 AG054533NIDA NIH HHS P50 DA042012NIH HHS S10 OD030452NIMH NIH HHS R01 MH130591NINDS NIH HHS R21 NS097945NINDS NIH HHS U24 NS124026
6 · The paper itselfAbstract
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in mouse models of Alzheimer's disease (AD). The current studies were designed to block noradrenergic signaling in 5XFAD mice through
Indexed as
Alzheimer’s Diseaseamyloid betaastrocytesbeta-adrenergic receptorbeta-blockeriDISCO+locus coeruleusmicroglianeuroinflammationnorepinephrine
Identifiers
PMID39574895
PMCPMC11581111
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