Evidence map›Paper›PMID 39574888›Full record

ArticleResearch square2024

Computational Mechanisms of Learning and Forgetting Differentiate Affective and Substance Use Disorders.

Navid Hakimi, Ko-Ping Chou, Jennifer L Stewart, Martin P Paulus, Ryan Smith

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Navid HakimiLaureate Institute for Brain Research, Tulsa, OK.
Ko-Ping ChouLaureate Institute for Brain Research, Tulsa, OK.ORCID https://orcid.org/0009-0001-8508-4746
Jennifer L StewartLaureate Institute for Brain Research, Tulsa, OK.ORCID https://orcid.org/0000-0003-0123-9438
Martin P PaulusLaureate Institute for Brain Research, Tulsa, OK.ORCID https://orcid.org/0000-0002-0825-3606
Ryan SmithLaureate Institute for Brain Research, Tulsa, OK.ORCID https://orcid.org/0000-0002-4448-185X

Funding

The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI MARTIN P. PAULUS · 2017 to 2026
$23.7M
Plasticity of Aversive Salience in Opioid Use DisorderR01DA050677 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI STEWART, JENNIFER LORRAINE · 2021 to 2025
$3.0M
NIDA NIH HHS R01 DA050677NIGMS NIH HHS P20 GM121312
6 · The paper itself

Abstract

Depression and anxiety are common, highly co-morbid conditions associated with a range of learning and decision-making deficits. While the computational mechanisms underlying these deficits have received growing attention, the transdiagnostic vs. diagnosis-specific nature of these mechanisms remains insufficiently characterized. Individuals with affective disorders (iADs; i.e., depression with or without co-morbid anxiety; N=168 and 74, respectively) completed a widely-used decision-making task. To establish diagnostic specificity, we also incorporated data from a sample of individuals with substance use disorders (iSUDs; N=147) and healthy comparisons (HCs; N=54). Computational modeling afforded separate measures of learning and forgetting rates, among other parameters. Compared to HCs, forgetting rates (reflecting recency bias) were elevated in both iADs and iSUDs (

Indexed as

active inferenceaffective disorderscomputational psychiatrydecision-makingexplore-exploit dilemmareinforcement learningsubstance use disorders

Identifiers

PMID39574888
PMCPMC11581052

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.