Evidence map›Paper›PMID 39574860›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Positive and negative affect, related mental health traits, and cognitive performance: shared genetic architecture and potential causality.

Chloe Slaney, Naoise Mac Giollabhui, Peter J van der Most, Ensor R Palacios, Harold Snieder, Michel Nivard, Gibran Hemani, Catharina A Hartman, Golam M Khandaker

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chloe SlaneyMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, UK.ORCID 0000-0003-0463-5516
Naoise Mac GiollabhuiDepression Clinical & Research Program, Department of Psychiatry, Massachusetts General Hospital, USA.ORCID 0000-0003-4226-5704
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, the Netherlands.ORCID 0000-0001-8450-3518
Ensor R PalaciosMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, UK.ORCID 0000-0001-8170-3397
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, the Netherlands.ORCID 0000-0003-1949-2298
Michel NivardMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, UK.ORCID 0000-0003-2015-1888
Gibran HemaniMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, UK.ORCID 0000-0003-0920-1055
Catharina A HartmanInterdisciplinary Center Psychopathology and Emotion Regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, the Netherlands.
Golam M KhandakerMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, UK.ORCID 0000-0002-4935-9220

Funding

The role of inflammation in cognitive dysfunction in acute depression as determined by experimental inhibition of tumor necrosis factor-alphasignaling in a randomized controlled trial.K23MH132893 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Naoise Mac Giollabhui · 2024 to 2026
$592k
Medical Research Council MC_UU_00032/6NIMH NIH HHS K23 MH132893Wellcome Trust
6 · The paper itself

Abstract

Altered affect and cognitive dysfunction are transdiagnostic, burdensome, and pervasive features of many psychiatric conditions which remain poorly understood and have few efficacious treatments. Research on the genetic architecture of these phenotypes and causal relationships between them may provide insight into their aetiology and comorbidity. Using data from the Lifelines Cohort Study, we conducted genome-wide association studies (GWAS) on positive and negative affect and four cognitive domains (working memory, reaction time, visual learning and memory, executive function). Using publicly available large GWAS on related - albeit distinct-phenotypes (depression, anxiety, wellbeing, general cognitive ability [GCA]) we conducted genetic correlation and Mendelian randomization (MR) analyses to examine genetic overlap and causal relationships. We identified one genome-wide hit (

Indexed as

AnxietyCognitionDepressionGeneral Cognitive AbilityGenetic CorrelationGWASLifelines CohortMendelian randomizationNegative AffectPositive Affect

Identifiers

PMID39574860
PMCPMC11581074

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.