Evidence map›Paper›PMID 39574752›Full record

ArticlebioRxiv : the preprint server for biology2024

TRPV4-mediated Mechanotransduction Regulates the Differentiation of Valvular Interstitial Cells to Myofibroblasts: Implications for Aortic Stenosis.

Pritha Mukherjee, Manisha Mahanty, Bidisha Dutta, Suneha G Rahaman, Karunakaran R Sankaran, Shaik O Rahaman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Pritha MukherjeeUniversity of Maryland, Department of Nutrition and Food Science, College Park, MD 20742.
Manisha MahantyUniversity of Maryland, Department of Nutrition and Food Science, College Park, MD 20742.
Bidisha DuttaUniversity of Maryland, Department of Nutrition and Food Science, College Park, MD 20742.
Suneha G RahamanUniversity of Maryland, Department of Nutrition and Food Science, College Park, MD 20742.
Karunakaran R SankaranUniversity of Maryland, Department of Nutrition and Food Science, College Park, MD 20742.
Shaik O RahamanUniversity of Maryland, Department of Nutrition and Food Science, College Park, MD 20742.

Funding

Role of TRPV4 mechanotransduction in foreign body responseR01EB024556 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI RAHAMAN, SHAIK O, ZHU, XIAOPING · 2017 to 2020
$1.7M
NIBIB NIH HHS R01 EB024556
6 · The paper itself

Abstract

As aortic valve stenosis (AVS) progresses, the valve tissue also stiffens. This increase in tissue stiffness causes the valvular interstitial cells (VICs) to transform into myofibroblasts in response. VIC-to-myofibroblast differentiation is critically involved in the development of AVS. Herein, we investigated the role of mechanosensitive Ca

Indexed as

Aortic Valve StenosisMechanotransductionTraction Force MicroscopyTransient Receptor Potential Vanilloid 4Valvular Interstitial Cell

Identifiers

PMID39574752
PMCPMC11580895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.