Evidence map›Paper›PMID 39574749›Full record

ArticlebioRxiv : the preprint server for biology2024

Influence of metal ions on the isothermal self-assembly of DNA nanostructures.

Arlin Rodriguez, Bharath Raj Madhanagopal, Kahini Sarkar, Zohreh Nowzari, Johnsi Mathivanan, Hannah Talbot, Vinod Morya, Ken Halvorsen, Sweta Vangaveti, J Andrew Berglund and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Arlin RodriguezThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.
Bharath Raj MadhanagopalThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.
Kahini SarkarThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.
Zohreh NowzariThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.
Johnsi MathivananThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.
Hannah TalbotThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.
Vinod MoryaThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.
Ken HalvorsenThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.
Sweta VangavetiThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.
J Andrew BerglundThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.
Arun Richard ChandrasekaranThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, USA.

Funding

Manipulating nucleic acids: applications in RNA biosensing, single-molecule analysis, and DNA nanotechnologyR35GM124720 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Ken A Halvorsen · 2017 to 2026
$4.6M
Design, Synthesis and Efficacy of New Small Molecule Therapeutics to Impede Myotonic DystrophyR01NS120485 · NINDS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Andrew Berglund, Masayuki Nakamori · 2022 to 2026
$2.7M
Alternative Splicing and Development of Small Molecule Therapeutics in CAG Expansion Spinocerebellar AtaxiasR01NS135254 · NINDS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Andrew Berglund, Damian Seung-Ho Shin · 2024 to 2026
$2.0M
Programmable DNA Nanostructures as Biomedical and Structural ScaffoldsR35GM150672 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Arun Richard Chandrasekaran · 2023 to 2026
$1.7M
DNA Nanostructures as siRNA Delivery Vehicles for Alzheimer's TherapyR03AG076599 · NIA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI CHANDRASEKARAN, ARUN RICHARD · 2022 to 2023
$425k
NIA NIH HHS R03 AG076599NIGMS NIH HHS R35 GM124720NIGMS NIH HHS R35 GM150672NINDS NIH HHS R01 NS120485NINDS NIH HHS R01 NS135254
6 · The paper itself

Abstract

DNA nanostructures are typically assembled by thermal annealing in buffers containing magnesium. We demonstrate the assembly of DNA nanostructures at constant temperatures ranging from 4 °C to 50 °C in solutions containing different metal ions. The choice of metal ions and the assembly temperature influence the isothermal assembly of several DNA motifs and designed three-dimensional DNA crystals. Molecular dynamics simulations show more fluctuations of the DNA structure in select monovalent ions (Na

Identifiers

PMID39574749
PMCPMC11580887

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.