Evidence map›Paper›PMID 39574717›Full record

ArticlebioRxiv : the preprint server for biology2025

In vivo cell-type and brain region classification via multimodal contrastive learning.

Han Yu, Hanrui Lyu, Ethan Yixun Xu, Charlie Windolf, Eric Kenji Lee, Fan Yang, Andrew M Shelton, Shawn Olsen, Sahar Minavi, Olivier Winter and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Han YuColumbia University, New York, NY, USA.ORCID 0000-0002-7110-7716
Hanrui LyuNorthwestern University, Evanston, IL, USA.ORCID 0000-0002-4349-8975
Ethan Yixun XuColumbia University, New York, NY, USA.
Charlie WindolfColumbia University, New York, NY, USA.ORCID 0000-0002-8360-7726
Eric Kenji LeeBoston University, Boston, MA, USA.ORCID 0000-0002-7166-0909
Fan YangUniversity College London, London, UK.
Andrew M SheltonAllen Institute, Seattle, WA, USA.ORCID 0000-0002-5787-4310
Shawn OlsenAllen Institute, Seattle, WA, USA.ORCID 0000-0002-9568-7057
Sahar MinaviAllen Institute, Seattle, WA, USA.
Olivier WinterChampalimaud Foundation, Lisbon, Portugal.ORCID 0000-0001-9278-2721
International Brain Laboratory
Eva L DyerGeorgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-6962-524X
Chandramouli ChandrasekaranBoston University, Boston, MA, USA.ORCID 0000-0002-1711-590X
Nicholas A SteinmetzUniversity of Washington, Seattle, WA, USA.ORCID 0000-0001-7029-2908
Liam PaninskiColumbia University, New York, NY, USA.ORCID 0000-0002-0276-7032
Cole HurwitzColumbia University, New York, NY, USA.ORCID 0000-0002-2023-1653

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
WaNPRC Macaca nemestrina SPF Breeding ColonyU42OD011123 · OD · UNIVERSITY OF WASHINGTON · PI Melissa R Berg, Cindy Buckmaster · 2012 to 2026
$34.4M
State-dependent Decision-making in Brainwide Neural CircuitsU19NS123716 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MRSIC-FLOGEL, THOMAS · 2021 to 2025
$18.2M
NeuropixelsUltra: Dense arrays for stable, unbiased, and cell type-specific electrical imagingU01NS113252 · NINDS · UNIVERSITY OF WASHINGTON · PI HARRIS, TIMOTHY D, OLSEN, SHAWN R. · 2019 to 2023
$3.8M
Multimodal Characterization of Prefrontal and Premotor Circuits Underlying Perceptual Decision Making in Therhesus MonkeyR01NS122969 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHANDRASEKARAN, CHANDRAMOULI, LUEBKE, JENNIFER I · 2021 to 2025
$3.1M
Linking Motor Cortex Activity and Movement in the Mouse Orofacial SystemR01NS121409 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Michael Nicholas Economo · 2022 to 2026
$2.1M
Causal Roles of Dorsolateral Prefrontal and Dorsal Premotor Cortex in Perceptual Decision-MakingR21NS135361 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHANDRASEKARAN, CHANDRAMOULI, RUSHMORE, RICHARD JARRETT · 2023 to 2023
$437k
Neural Circuit Dynamics Underlying Perceptual Decision Making in the Macaque Dorsolateral Prefrontal CortexF31NS131018 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LEE, ERIC KENJI · 2024 to 2025
$75k
NIH HHS P51 OD010425NIH HHS U42 OD011123NINDS NIH HHS F31 NS131018NINDS NIH HHS R01 NS121409NINDS NIH HHS R01 NS122969NINDS NIH HHS R21 NS135361NINDS NIH HHS U01 NS113252NINDS NIH HHS U19 NS123716Wellcome Trust
6 · The paper itself

Abstract

Current electrophysiological approaches can track the activity of many neurons, yet it is usually unknown which cell-types or brain areas are being recorded without further molecular or histological analysis. Developing accurate and scalable algorithms for identifying the cell-type and brain region of recorded neurons is thus crucial for improving our understanding of neural computation. In this work, we develop a multimodal contrastive learning approach for neural data that can be fine-tuned for different downstream tasks, including inference of cell-type and brain location. We utilize this approach to jointly embed the activity autocorrelations and extracellular waveforms of individual neurons. We demonstrate that our embedding approach,

Identifiers

PMID39574717
PMCPMC11580900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.