Evidence map›Paper›PMID 39574639›Full record

ArticlebioRxiv : the preprint server for biology2024

Molecular Signatures of Resilience to Alzheimer's Disease in Neocortical Layer 4 Neurons.

S Akila Parvathy Dharshini, Jorge Sanz-Ros, Jie Pan, Weijing Tang, Kristen Vallejo, Marcos Otero-Garcia, Inma Cobos

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

S Akila Parvathy DharshiniDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jorge Sanz-RosDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jie PanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Weijing TangDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kristen VallejoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Marcos Otero-GarciaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Inma CobosDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-2043-1890

Funding

Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0M
Resolving selective vulnerability and disease progression in human Alzheimer's brain via single-cell RNA-seqR01AG059848 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COBOS, INMA · 2018 to 2022
$2.0M
NIA NIH HHS P30 AG066515NIA NIH HHS R01 AG059848
6 · The paper itself

Abstract

Single-cell omics is advancing our understanding of selective neuronal vulnerability in Alzheimer's disease (AD), revealing specific subtypes that are either susceptible or resilient to neurodegeneration. Using single-nucleus and spatial transcriptomics to compare neocortical regions affected early (prefrontal cortex and precuneus) or late (primary visual cortex) in AD, we identified a resilient excitatory population in layer 4 of the primary visual cortex expressing

Identifiers

PMID39574639
PMCPMC11580857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.