Evidence map›Paper›PMID 39574593›Full record

ArticlebioRxiv : the preprint server for biology2024

DISTANT RIBOSE 2'-O-METHYLATION OF 23S rRNA HELIX 69 PRE-ORDERS THE CAPREOMYCIN DRUG BINDING POCKET AT THE RIBOSOME SUBUNIT INTERFACE.

Suparno Nandi, Debayan Dey, Pooja Srinivas, Christine M Dunham, Graeme L Conn

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Suparno NandiDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.ORCID 0000-0002-3534-8002
Debayan DeyDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.ORCID 0000-0002-0222-6092
Pooja SrinivasDepartment of Chemistry, Emory University, Atlanta, Georgia, 30322, USA.ORCID 0000-0001-7796-8827
Christine M DunhamDepartment of Chemistry, Emory University, Atlanta, Georgia, 30322, USA.ORCID 0000-0002-8821-688X
Graeme L ConnDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.ORCID 0000-0002-2419-380X

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
RNA modification and antibiotic resistanceR01AI088025 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Christine M Dunham · 2010 to 2026
$7.9M
Graduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1M
Antimicrobial Resistance and Therapeutic Discovery Training ProgramT32AI106699 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Joanna B Goldberg · 2014 to 2026
$2.7M
NIAID NIH HHS R01 AI088025NIAID NIH HHS T32 AI106699NIGMS NIH HHS T32 GM008602NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

Loss of ribosomal RNA (rRNA) modifications incorporated by the intrinsic methyltransferase TlyA results in reduced sensitivity to tuberactinomycin antibiotics such as capreomycin. However, the mechanism by which rRNA methylation alters drug binding, particularly at the distant but functionally more important site in 23S rRNA Helix 69 (H69), is currently unknown. We determined high-resolution cryo-electron microscopy structures of the

Indexed as

antibiotic resistancecapreomycinribosomeRNA modification

Identifiers

PMID39574593
PMCPMC11580936

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.