Evidence map›Paper›PMID 39574587›Full record

ArticlebioRxiv : the preprint server for biology2024

Critical role of Spatio-Temporally Regulated Maternal RNAs in Zebrafish Embryogenesis.

Gopal Kushawah, Danielson Baia Amaral, Huzaifa Hassan, Madelaine Gogol, Stephanie H Nowotarski, Ariel A Bazzini

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gopal KushawahStowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA.
Danielson Baia AmaralStowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA.
Huzaifa HassanStowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA.
Madelaine GogolStowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA.
Stephanie H NowotarskiStowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA.ORCID 0000-0003-2569-1939
Ariel A BazziniStowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA.

Funding

Small translated ORFs in the 3'UTR enhance translation in vertebratesR01GM136849 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI BAZZINI, ARIEL · 2021 to 2025
$2.0M
CRISPR-Cas13d: Transgenic zebrafish lines toknockdown mRNAR21OD034161 · OD · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI BAZZINI, ARIEL · 2023 to 2024
$454k
NIGMS NIH HHS R01 GM136849NIH HHS R21 OD034161
6 · The paper itself

Abstract

The maternal-to-zygotic transition shifts regulatory control from maternal to zygotic messenger RNAs (mRNA) through maternal mRNA degradation. While temporal aspects of maternal mRNA decay are known, spatial mechanisms remain underexplored. Using CRISPR-Cas9 and CRISPR-Cas13d systems, we functionally dissected the contribution of maternal versus zygotic fractions and overcame challenges of studying embryonic lethal genes. We identified differentially distributed maternal mRNAs in specific cells and evidenced the critical role of five maternal mRNAs,

Indexed as

CRISPR-Cas13dCRISPR-Cas9Cth1Embryonic lethalGametogenesisMZTRNA decayRNA-decay factorSpatio-temporal maternal RNAsZebrafish

Identifiers

PMID39574587
PMCPMC11580991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.