Evidence map›Paper›PMID 39574582›Full record

ArticlebioRxiv : the preprint server for biology2024

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.

Ella W Mathews, Sydney R Coffey, Annette Gärtner, Jillian Belgrad, Robert M Bragg, Daniel O'Reilly, Jeffrey P Cantle, Cassandra McHugh, Ashley Summers, Joachim Fentz and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Ella W MathewsDepartment of Neurology, University of Washington, Seattle WA 98104, USA.
Sydney R CoffeyDepartment of Psychology, Western Washington University, Bellingham WA 98225, USA.
Annette GärtnerEvotec SE, Hamburg, Germany.
Jillian BelgradRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Robert M BraggDepartment of Neurology, University of Washington, Seattle WA 98104, USA.
Daniel O'ReillyRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Jeffrey P CantleDepartment of Neurology, University of Washington, Seattle WA 98104, USA.
Cassandra McHughDepartment of Psychology, Western Washington University, Bellingham WA 98225, USA.
Ashley SummersRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Joachim FentzEvotec SE, Hamburg, Germany.
Tom SchwagarusEvotec SE, Hamburg, Germany.
Antje CorneliusEvotec SE, Hamburg, Germany.
Ioannis LingosEvotec SE, Hamburg, Germany.
Zoe BurchCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Marina KovalenkoCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Marissa A AndrewCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
C Frank BennettIonis Pharmaceuticals, Carlsbad, CA 92010, USA.
Holly B KordasiewiczIonis Pharmaceuticals, Carlsbad, CA 92010, USA.
Deanna M MarchioniniCHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation Inc., Princeton, NJ 08540, USA.
Hilary WilkinsonCHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation Inc., Princeton, NJ 08540, USA.
Thomas F VogtCHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation Inc., Princeton, NJ 08540, USA.
Ricardo M PintoCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Anastasia KhvorovaRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
David HowlandCHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation Inc., Princeton, NJ 08540, USA.
Vanessa C WheelerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jeffrey B CarrollDepartment of Neurology, University of Washington, Seattle WA 98104, USA.

Funding

Huntington's Disease Repeat Instability and PathogenesisR01NS049206 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VANESSA C WHEELER · 2005 to 2026
$10.0M
NINDS NIH HHS R01 NS049206
6 · The paper itself

Abstract

Huntington's disease (HD) arises from a CAG expansion in the

Identifiers

PMID39574582
PMCPMC11580907

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.