Evidence map›Paper›PMID 39574580›Full record

ArticlebioRxiv : the preprint server for biology2024

Perineuronal nets on CA2 pyramidal cells and parvalbumin-expressing cells differentially regulate hippocampal dependent memory.

Georgia M Alexander, Viktoriya D Nikolova, Tristan M Stöber, Artiom Gruzdev, Sheryl S Moy, Serena M Dudek

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Georgia M AlexanderNeurobiology Laboratory, National Institute of Environmental Health Sciences, Division of Intramural Research, National Institute of Health, Research Triangle Park, North Carolina 27713, USA.ORCID 0000-0003-4245-4417
Viktoriya D NikolovaCarolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.
Tristan M StöberInstitute for Neuroinformatics, Ruhr, University Bochum, Bochum, Germany.
Artiom GruzdevGenome Editing and Mouse Model Core Facility, National Institute of Environmental Health Sciences, Division of Intramural Research, National Institute of Health, Research Triangle Park, North Carolina 27713, USA.
Sheryl S MoyCarolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.
Serena M DudekNeurobiology Laboratory, National Institute of Environmental Health Sciences, Division of Intramural Research, National Institute of Health, Research Triangle Park, North Carolina 27713, USA.ORCID 0000-0003-4094-8368

Funding

Neurobehavioral Core LaboratoryZICES103330 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CUSHMAN, JESSE · 2018 to 2025
$13.3M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Synaptic Plasticity In The Adult And Developing NSZ01ES100221 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DUDEK, SERENA M · 2002 to 2008
$3.5M
Intramural NIH HHS Z01 ES100221Intramural NIH HHS ZIC ES103330NICHD NIH HHS P50 HD103573
6 · The paper itself

Abstract

Perineuronal nets (PNNs) are a specialized extracellular matrix that surround certain populations of neurons, including (inhibitory) parvalbumin (PV) expressing-interneurons throughout the brain and (excitatory) CA2 pyramidal neurons in hippocampus. PNNs are thought to regulate synaptic plasticity by stabilizing synapses and as such, could regulate learning and memory. Most often, PNN functions are queried using enzymatic degradation with chondroitinase, but that approach does not differentiate PNNs on CA2 neurons from those on adjacent PV cells. To disentangle the specific roles of PNNs on CA2 pyramidal cells and PV neurons in behavior, we generated conditional knockout mouse strains with the primary protein component of PNNs, aggrecan (

Identifiers

PMID39574580
PMCPMC11581025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.