Evidence map›Paper›PMID 39574346›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Local Exosome Inhibition Potentiates Mild Photothermal Immunotherapy Against Breast Cancer.

Qian Chen, Yanan Li, Jiameng Hu, Zhenyu Xu, Shengyi Wang, Naicong Cai, Mengjiao He, Yifang Xiao, Yuan Ding, Mengjuan Sun and 9 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Local Exosome Inhibition Potentiates Mild Photothermal Immunotherapy Against Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Qian ChenState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Yanan LiSchool of Food and Pharmaceutical Engineering, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing, 210023, China.
Jiameng HuSchool of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Zhenyu XuState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Shengyi WangState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Naicong CaiState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Mengjiao HeState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Yifang XiaoState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Yuan DingDepartment of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Mengjuan SunState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Chunjiayu LiState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Yiyang CaoState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Zhongyuan WangState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Fang ZhouState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Guangji WangState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Chen WangState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Jiasheng TuState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Haiyang HuState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Chunmeng SunState Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.ORCID 0000-0002-6588-6047

Funding

China Postdoctoral Science Foundation 2023M733891Fundamental Research Funds for the Central Universities 2632023GR11Jiangsu Funding Program for Excellent Postdoctoral Talent 317717National Natural Science Foundation of China 22478438National Natural Science Foundation of China 81972894National Natural Science Foundation of China 82273882National Natural Science Foundation of China 82303820Natural Science Foundation of Jiangsu Province BK20231017Science Fund for Distinguished Young Scholars of Jiangsu Province BK20240098Special Research Fund from the State Key Laboratory of Natural Medicines at China Pharmaceutical University SKLNMZZ2024JS19
6 · The paper itself

Abstract

Limited immune infiltration within the tumor microenvironment (TME) hampers the efficacy of immune checkpoint blockade (ICB) therapy. To enhance immune infiltration, mild photothermal therapy (PTT) is often combined with immunotherapy. However, the impact of mild PTT on the TME remains unclear. The bioinformatics analyses reveal that mild PTT amplifies immune cell infiltration and stimulates T-cell activity. Notably, it accelerates the release of tumor cell-derived exosomes (T

Indexed as

Breast NeoplasmsExosomesImmunotherapyPhotothermal TherapyAnimalsB7-H1 AntigenCell Line, TumorFemaleGraphiteHumansImmune Checkpoint InhibitorsMicePhotosensitizing AgentsTumor MicroenvironmentB7-H1 Antigengraphene oxideGraphiteImmune Checkpoint InhibitorsPhotosensitizing Agentscombination immunotherapyexosome inhibitionimmune checkpoint blockademild photothermal therapymultistage drug depot

Identifiers

PMID39574346
PMCPMC11727390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.