SynthesisSchizophrenia bulletin2025
A Systematic Review and Meta-Analysis on Contrast Sensitivity in Schizophrenia.
Synthesis in Schizophrenia bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stereopsis deficits in schizophrenia: a systematic review with exploratory meta-analysis.BMC psychiatry · 2026Pooled it
- Retinal Origins of Aberrant Salience in Schizophrenia: The Perceptual Theory.Biological psychiatry global open science · 2026Review
- Contrast sensitivity and subjective visual disturbances across the psychosis continuum.Cognitive neuropsychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and hypothesisUnderstanding perceptual alterations in mental disorders can help uncover neural and computational anomalies. In schizophrenia, perceptual alterations have been reported for many visual features, including a deficit in contrast sensitivity, a key measure of visual function. The evidence supporting this deficit, however, has not been comprehensively synthesized. STUDY
designWe conducted a systematic review and meta-analysis of studies measuring contrast sensitivity in individuals with schizophrenia and healthy controls. Our search identified 46 studies, of which 43 focused on chronic patients. STUDY
resultsWe found that patients with chronic schizophrenia have reduced contrast sensitivity (g = 0.74; 95% CI, 0.55 to 0.93; P = 8.2 × 10-10). However, we found evidence that the deficit could be driven by medication. Additionally, none of the studies estimated attentional lapses, leaving it uncertain whether a potentially higher frequency of lapses in patients contributes to the observed deficit. Furthermore, only two studies comprehensively assessed visual acuity, complicating the understanding of the role of spatial frequency in the observed deficit.
conclusionsWhile we identified a robust deficit in contrast sensitivity among chronic schizophrenia patients, the influence of attentional lapses and medication on this impairment remains unclear. We make several suggestions for future research to clarify the underlying mechanisms contributing to this deficit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.