Evidence map›Paper›PMID 39574303›Full record

ArticleACS chemical neuroscience2024

Stereospecific Properties and Intracellular Transport of Novel Intrinsically Fluorescent Neurosteroids.

Vibeke Akkerman, Peter Reinholdt, Rasmus Schnoor-Madsen, Line Lauritsen, Jad Bader, Minxing Qian, Yuanjiang Xu, Gustav Akk, Holger A Scheidt, Peter Müller and 4 more

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. New directions in neurosteroid therapeutics in neuropsychiatry.Neuroscience and biobehavioral reviews · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vibeke AkkermanDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
Peter ReinholdtDepartment of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.ORCID 0000-0003-2406-700X
Rasmus Schnoor-MadsenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
Line LauritsenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
Jad BaderDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110, United States.
Minxing QianDepartment of Developmental Biology, Washington University in St. Louis, St. Louis, Missouri 63110, United States.
Yuanjiang XuDepartment of Developmental Biology, Washington University in St. Louis, St. Louis, Missouri 63110, United States.
Gustav AkkDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110, United States.ORCID 0000-0001-6677-0655
Holger A ScheidtInstitute for Medical Physics and Biophysics, Leipzig University, Härtelstr. 16-18, 04107 Leipzig, Germany.ORCID 0000-0001-9935-8229
Peter MüllerDepartment of Biology, Humboldt University Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
Douglas F CoveyDepartment of Developmental Biology and Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, Missouri 63110, United States.ORCID 0000-0002-9316-8683
Alex S EversDepartment of Developmental Biology and Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, Missouri 63110, United States.ORCID 0000-0002-0342-0575
Jacob KongstedDepartment of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.ORCID 0000-0002-7725-2164
Daniel WüstnerDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.ORCID 0000-0003-4995-9709

Funding

Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2021 to 2025
$12.2M
Neurosteroid and Cholesterol Binding to Integral Membrane ProteinsR35GM149287 · NIGMS · WASHINGTON UNIVERSITY · PI ALEX S. EVERS · 2023 to 2026
$2.4M
GABAA receptors: function, physiology and involvement in anesthesiaR35GM140947 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2021 to 2025
$1.8M
NIGMS NIH HHS R35 GM140947NIGMS NIH HHS R35 GM149287NIMH NIH HHS P50 MH122379
6 · The paper itself

Abstract

Allopregnanolone (AlloP) is an example of neuroactive steroids (NAS), which is a potent allosteric activator of the γ-aminobutyric acid A (GABA

Indexed as

NeurosteroidsPregnanoloneReceptors, GABA-AAnimalsBiological TransportFluorescence Resonance Energy TransferFluorescent DyesHumansStereoisomerismFluorescent DyesNeurosteroidsPregnanoloneReceptors, GABA-Aallopregnanoloneastrocytesfluorescencemicroscopyprobestrafficking

Identifiers

PMID39574303
PMCPMC11892034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.