Evidence map›Paper›PMID 39574208›Full record

ArticleJournal of surgical oncology2025

Analysis of Risk Factors, Treatment Patterns, and Survival Outcomes After Emergency Presentation With Colorectal Cancer: A Prospective Multicenter Cohort Study in Nigeria.

Adeniyi S Aderibigbe, Anna J Dare, Hannah L Kalvin, Olalekan Olasehinde, Funmilola Wuraola, Adewale Adisa, Adeleye Dorcas Omisore, Akinwumi O Komolafe, Oluwatosin Zainab Omoyiola, Chukwuma Eze Okereke and 20 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Adeniyi S AderibigbeDepartment of Surgery, Federal Medical Center, Owo, Ondo State, Nigeria.
Anna J DareDepartment of Surgery, St. Michael's Hospital & University of Toronto, Toronto, Ontario, Canada.
Hannah L KalvinDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Olalekan OlasehindeDepartment of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria.ORCID http://orcid.org/0000-0002-8706-0756
Funmilola WuraolaDepartment of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria.
Adewale AdisaDepartment of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria.
Adeleye Dorcas OmisoreDepartment of Radiology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria.
Akinwumi O KomolafeDepartment of Morbid Anatomy, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria.
Oluwatosin Zainab OmoyiolaDepartment of Morbid Anatomy, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria.
Chukwuma Eze OkerekeDepartment of Surgery, Federal Medical Center, Owo, Ondo State, Nigeria.
Aba KatungDepartment of Surgery, Federal Medical Center, Owo, Ondo State, Nigeria.
Adedeji EgberoungbeDepartment of Radiology, Federal Medical Center, Owo, Ondo State, Nigeria.
Olufemi AriyibiDepartment of Morbid Anatomy, Federal Medical Center, Owo, Ondo State, Nigeria.
Samuel Adegboyega OlatokeDepartment of Surgery, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
Ademola Adetoyese AdeyeyeDepartment of Surgery, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
Sulaiman Olayide AgodirinDepartment of Surgery, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
Matthew Olumuyiwa BojuwoyeDepartment of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
James Oluwaleke FayenuwoAfrican Research Group for Oncology, Ife, Osun State, Nigeria.
Oluwabusayomi Roseline AdemakinwaAfrican Research Group for Oncology, Ife, Osun State, Nigeria.
Dapo OsinowoDepartment of Pathology, Lagos University Teaching Hospital, College of Medicine, University of Lagos, Lagos, Nigeria.
Abdul-Razak LawalDepartment of Pathology, Lagos University Teaching Hospital, College of Medicine, University of Lagos, Lagos, Nigeria.
Fatimah B AbdulkareemDepartment of Pathology, Lagos University Teaching Hospital, College of Medicine, University of Lagos, Lagos, Nigeria.
Debra GoldmanDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gregory KnappDepartment of Surgery, Division of General Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.
Shilpa MurthyDepartment of Surgery, Yale School of Medicine, New Haven, Connecticut, USA.
Rivka KahnGlobal Cancer Disparities Initiative, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Mithat GonenDepartment of Surgery, Federal Medical Center, Owo, Ondo State, Nigeria.
T Peter KinghamGlobal Cancer Disparities Initiative, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Olusegun I AlatiseDepartment of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria.
African Research Group in Oncology Colorectal Cancer Working Group

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Expanding cancer research capacity in Nigeria with team scienceD43CA260646 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI T PETER KINGHAM · 2022 to 2026
$1.4M
NCI NIH HHS P30 CA008748This study was supported by National Institutes of Health (P30 CA008748) and the Thompson Family Foundation.
6 · The paper itself

Abstract

BACKGROUND AND

objectivesProspective data on presentation and outcomes of colorectal cancer (CRC) in Nigeria are limited; however, emergency presentation with advanced disease is thought common.

methodsConsecutive CRC patients presenting at six sites over 6 years were included. Risk factors for emergency presentation were evaluated using logistic regression methods. Overall survival (OS) was compared between emergent and elective patients using Kaplan-Meier methods and the log-rank test.

resultsOf 535 patients, 30.7% presented emergently. Median age was 56 years, 55% were men, and 5.0% reported a cancer family history. Emergency patients had more proximal cancers (42.1% vs. 24.0%), Stage IV disease (61.6% vs. 40.2%; p < 0.001), lower household income (₦35 000/month vs. ₦50 000/month), lower education levels (p = 0.008) and accessed care with nonmotorized transport (50.6% vs. 37.2%; p = 0.005). Median OS was shorter in the emergency group (6.4 vs. 17.4 months; p < 0.001). Across clinical stages, emergency presentation was associated with worse OS (Stage IV median OS 4.8 vs. 9.4 months; p = 0.002). Surgery improved survival in both groups, although emergency patients had higher 30-day postoperative mortality (23.2% vs. 9.1%; p < 0.001).

conclusionsEmergent Nigerian CRC patients have worse OS than elective patients. Cancer control efforts should focus on faster cancer detection, early presentation, diagnosis, and treatment.

Indexed as

Colorectal NeoplasmsAdultAgedEmergenciesFemaleFollow-Up StudiesHumansMaleMiddle AgedNigeriaPrognosisProspective StudiesRisk FactorsSurvival Ratecancer survivalcolorectal canceremergency presentationlow‐ and middle‐income countries (LMICs)NigeriaWest Africa

Identifiers

PMID39574208
PMCPMC13178191

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.