Evidence map›Paper›PMID 39574168›Full record

ReviewClinical epigenetics2024

Advances in the study of posttranslational modifications of histones in head and neck squamous cell carcinoma.

Yuyang Xiao, Yikai Zhang, Yuyang Hu, Xupeng Zhang, Jiaqi Tan, Shanhu Yao, Xingwei Wang, Yuexiang Qin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. [Research progress on the mechanisms of resistance to cetuximab targeted therapy in head and neck squamous cell carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuyang XiaoDepartment of Health Management Medical, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Yikai ZhangDepartment of Health Management Medical, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Yuyang HuDepartment of Health Management Medical, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Xupeng ZhangDepartment of Health Management Medical, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Jiaqi TanDepartment of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China.
Shanhu YaoDepartment of Radiology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan Province, China.
Xingwei WangDepartment of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China. 371156510@qq.com.
Yuexiang QinDepartment of Health Management Medical, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China. 602466@csu.edu.cn.

Funding

China Postdoctoral Science Foundation 2022M723559National Natural Science Foundation of China 82303133Natural Science Foundation of Hunan Province 2021JJ40951Natural Science Foundation of Hunan Province 2022JJ30963Project of Hunan Health Commission B202307017799Project of Hunan Health Commission B202309018525
6 · The paper itself

Abstract

The pathogenesis of head and neck squamous cell carcinoma (HNSCC) is notably complex. Early symptoms are often subtle, and effective early screening methods are currently lacking. The tumors associated with HNSCC develop rapidly, exhibit high aggressiveness, and respond poorly to existing treatments, leading to low survival rates and poor prognosis. Numerous studies have demonstrated that histone posttranslational modifications (HPTMs), including acetylation, methylation, phosphorylation, and ubiquitination, play a critical role in the occurrence and progression of HNSCC. Moreover, targeting histone posttranslationally modified molecules with specific drugs has shown potential in enhancing therapeutic outcomes and improving prognosis, underscoring their significant clinical value. This review aims to summarize the role of histone posttranslational modifications in the pathogenesis and progression of HNSCC and to discuss their clinical significance, thereby providing insights into novel therapeutic approaches and drug development for this malignancy.

Indexed as

Head and Neck NeoplasmsHistonesProtein Processing, Post-TranslationalSquamous Cell Carcinoma of Head and NeckAcetylationEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMethylationPhosphorylationPrognosisUbiquitinationHistonesEpigeneticsHead and neck squamous cell carcinomaHistone inhibitorsHistone posttranslational modifications

Identifiers

PMID39574168
PMCPMC11580233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.