Evidence map›Paper›PMID 39574021›Full record

ArticleBMC cancer2024

Palliative care of proximal femur metastatic disease and osteolytic lesions: results following surgical and radiation treatment.

Elisabeth Mehnert, Fränze Sophie Möller, Christine Hofbauer, Anne Weidlich, Doreen Winkler, Esther G C Troost, Christina Jentsch, Konrad Kamin, Marcel Mäder, Klaus-Dieter Schaser and 1 more

Abstract read
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In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Surgical treatment options for bone metastases].Chirurgie (Heidelberg, Germany) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elisabeth MehnertUniversity Center of Orthopedic, Trauma and Plastic Surgery, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Elisabeth.Mehnert@uniklinikum-dresden.de.
Fränze Sophie MöllerUniversity Center of Orthopedic, Trauma and Plastic Surgery, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Christine HofbauerNational Center for Tumor Diseases (NCT/UCC), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany.
Anne WeidlichUniversity Center of Orthopedic, Trauma and Plastic Surgery, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Doreen WinklerUniversity Center of Orthopedic, Trauma and Plastic Surgery, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Esther G C TroostNational Center for Tumor Diseases (NCT/UCC), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany.
Christina JentschNational Center for Tumor Diseases (NCT/UCC), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany.
Konrad KaminUniversity Center of Orthopedic, Trauma and Plastic Surgery, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Marcel MäderUniversity Center of Orthopedic, Trauma and Plastic Surgery, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Klaus-Dieter SchaserUniversity Center of Orthopedic, Trauma and Plastic Surgery, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Hagen FritzscheUniversity Center of Orthopedic, Trauma and Plastic Surgery, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFemoral bone metastases (FBM) or lesions (FBL) can lead to loss of mobility and independence due to skeletal-related events (SRE), e.g. pain, deformity and pathological fractures. Aim of this study was to analyze effects of radiotherapy and surgery, different surgical techniques and complications on disease-specific survival (DSS).

methodsPatients who underwent palliative therapy for FBM or FBL between 2014 and 2020 were retrospectively analyzed. Chi-square test was used to detect intergroup differences. Survival was calculated using Kaplan-Meier method, Cox regression and compared using log-rank test. Complications were evaluated using Chi-Square test.

results145 patients were treated for proximal femoral BM/BL or pathologic fractures (10 bilaterally). Three groups were classified: surgery only (S, n = 53), surgery with adjuvant radiation (S + RT, n = 58), and primary radiation only (RT, n = 44). Most common primary tumors were breast (n = 31), prostate (n = 27), and non-small cell lung cancer (n = 27). 47 patients underwent surgery for an impending, 61 for a manifest pathological fracture. There were no significant differences in DSS between the 3 groups (S = 29.8, S + RT = 32.2, RT = 27.1 months), with the S + RT group having the longest one-year survival. Local complications occurred in 25 of 145 patients after a mean interval of 9.9 months.

conclusionDue to the steadily increasing incidence and survival of patients with FBM/FBL, indication for prevention and treatment of painful and immobilizing SREs should be critically assessed. Surgical treatment should always be performed with maximum stability and, whenever possible, adjuvant RT.

Indexed as

Palliative CareAdultAgedAged, 80 and overBone NeoplasmsBreast NeoplasmsFemaleFemoral NeoplasmsFemurFractures, SpontaneousHumansKaplan-Meier EstimateMaleMiddle AgedOsteolysisProstatic NeoplasmsImpending fractureIntramedullary nailingMultimodal cancer therapiesOsteolytic bone lesionsPathological fractureProximal femoral metastasisSkeletal-related events

Identifiers

PMID39574021
PMCPMC11580346

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.