Evidence map›Paper›PMID 39574018›Full record

SynthesisBMC infectious diseases2024

Measles vaccine effectiveness in African children: a systematic review and meta-analysis.

Demeke Endalamaw, Endalkachew Nibret, Abaineh Munshea, Feleke Mekonnen, Senait Tadesse, Taye Zeru, Mesfine Tefera, Gizachew Yismaw

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Demeke EndalamawVirology Research, Amhara Public Health Institute (APHI), Bahir Dar, Ethiopia. demekeendalamaw@gmail.com.
Endalkachew NibretHealth Biotechnology Divisions, Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia.
Abaineh MunsheaHealth Biotechnology Divisions, Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia.
Feleke MekonnenMedical Laboratory Science Department, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Senait TadesseMedical Laboratory Science Department, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Taye ZeruNeglected and Tropical Diseases Researcher, Amhara Public Health Institute (APHI), Bahir Dar, Ethiopia.
Mesfine TeferaNational Polio and Measles Laboratory, Ethiopian Public Health Institute (EPHI), Addis Ababa, Ethiopia.
Gizachew YismawAmhara Public Health Institute (APHI), Bahir Dar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMeasles is an extremely contagious viral disease that can be prevented through vaccination. It is caused by the measles virus and presents with symptoms such as high fever, cough, runny nose, conjunctivitis, and a distinctive rash. Complications may include pneumonia, diarrhoea, and neurological issues. The disease spreads through respiratory droplets and continues to pose a significant public health challenge, especially in Africa, despite vaccination efforts.

objectiveThis systematic review and meta-analysis aim to estimate the pooled vaccine effectiveness of measles vaccines among African children, providing insights into immunization program success and informing policy decisions on vaccine distribution and resource allocation.

methodsFollowing PRISMA guidelines, search was conducted in databases including PubMed/Medline, Science Direct, HINARI, Cochrane/Wiley library, Europe PMC, and grey literatures like Google Scholar up to March 2024. Cross-sectional studies assessed measles vaccine effectiveness in African children aged nine months and above were included. Data was extracted using JBI extraction tool and entered into microsoft excel and analysed via STATA version 20.1 using random effect model.

resultsFrom 5295 identified articles, 18 met the inclusion criteria, encompassing 26,470 children from 13 African countries. The pooled measles vaccine effectiveness was 68.58%, with significant heterogeneity (I2 = 99.66%, p < 0.001). Subgroup analysis showed variability in vaccine effectiveness by study period, with higher effectiveness in studies conducted after the Global Vaccine Action Plan (GVAP) in 2012.

conclusionMeasles vaccine effectiveness varies in African regions, ranging from 98.4% in Nigeria to 36.5% in Mozambique, with an overall effectiveness of 68.58% and high heterogeneity among studies. Optimizing vaccine distribution, increasing coverage, and prompt administration are important for enhancing effectiveness. Continued support for GVAP strategies and further research is needed to understand factors affecting vaccine performance and improve immunization efforts in Africa.

Indexed as

MeaslesMeasles VaccineVaccine EfficacyAfricaChildChild, PreschoolHumansImmunization ProgramsInfantVaccinationMeasles VaccineAfrican childrenMeasles vaccineVaccine effectivenessVaccine effectiveness systematic review

Identifiers

PMID39574018
PMCPMC11583540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.