Evidence map›Paper›PMID 39573918›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Sox6 and ALDH1A1 Truncation by Asparagine Endopeptidase Defines Selective Neuronal Vulnerability in Parkinson's Disease.

Shuke Nie, Bowei Li, Mengmeng Wang, Zijun Chen, Jiayan Ren, Zixuan Li, Xinli Xu, Zhengjiang Qian, Zhongyun Xie, Jianxin Han and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shuke NieDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.ORCID 0000-0003-3776-2749
Bowei LiBrain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
Mengmeng WangBrain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
Zijun ChenBrain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
Jiayan RenGuangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, BCBDI, SIAT, Chinese Academy of Sciences, Shenzhen, 518055, China.
Zixuan LiGuangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, BCBDI, SIAT, Chinese Academy of Sciences, Shenzhen, 518055, China.
Xinli XuGuangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, BCBDI, SIAT, Chinese Academy of Sciences, Shenzhen, 518055, China.
Zhengjiang QianBrain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
Zhongyun XieBrain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
Jianxin HanBrain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
Zhentao Zhang
Zhaohui ZhangDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Yingjie ZhuShenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, BCBDI, SIAT, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China.
Zuxin ChenGuangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, BCBDI, SIAT, Chinese Academy of Sciences, Shenzhen, 518055, China.
Xifei YangKey Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, 518055, China.
Keqiang YeBrain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515030296National Natural Science Foundation of China 32330040National Natural Science Foundation of China 82350710222Natural Science Foundation of Hubei Province 2021CFB451Shenzhen Government Basic Research Program JCYJ20220531100802005
6 · The paper itself

Abstract

Dopaminergic neurons in the substantia nigra pars compacta (SNpc) demonstrate regionally selective susceptibility in Parkinson's disease (PD) compared to those in the ventral tegmental area (VTA). However, the molecular mechanism for this distinct vulnerability remains unclear. Here, it is shown that Legumain, also known as asparagine endopeptidase (AEP), is activated in a subgroup of SRY-box transcription factor 6 /Aldehyde dehydrogenase 1 family member A1, (Sox6

Indexed as

Aldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyDopaminergic NeuronsParkinson DiseaseRetinal DehydrogenaseSOXD Transcription FactorsAnimalsAsparaginyl EndopeptidaseCysteine EndopeptidasesHumansMaleMiceAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, mouseAsparaginyl EndopeptidaseCysteine EndopeptidasesRetinal DehydrogenaseSOXD Transcription FactorsALDH1A1asparagine endopeptidaseparkinson's diseaseSox6vulnerability

Identifiers

PMID39573918
PMCPMC11727119

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.