Evidence map›Paper›PMID 39573859›Full record

SynthesisJournal of surgical oncology2025

A Systematic Review and Meta-Analysis of Oncologic Liver Resections in Low- and Middle-Income Countries: Opportunities to Improve Evidence and Outcomes.

Adel H Khan, Omar Mahmud, Asad Saulat Fatimi, Shaheer Ahmed, Alyssa A Wiener, Madhuri V Nishtala, Christopher C Stahl, Leslie Christensen, Muhammad Rizwan Khan, Patrick B Schwartz and 1 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adel H KhanKhyber Medical College, Peshawar, Pakistan.
Omar MahmudMedical College, Aga Khan University, Karachi, Pakistan.ORCID http://orcid.org/0000-0001-6514-1646
Asad Saulat FatimiMedical College, Aga Khan University, Karachi, Pakistan.
Shaheer AhmedIslamabad Medical and Dental College, Islamabad, Pakistan.
Alyssa A WienerDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID http://orcid.org/0000-0002-6101-8138
Madhuri V NishtalaDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Christopher C StahlDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Leslie ChristensenEbling Library, University of Wisconsin, Madison, Wisconsin, USA.
Muhammad Rizwan KhanDepartment of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
Patrick B SchwartzDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Syed Nabeel ZafarDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

backgroundPatients in low- and middle-income countries (LMICs) are disproportionately affected by liver cancers but there is a lack of understanding of their postoperative outcomes. This study aimed to review the current status of research in LMICs regarding outcomes after oncologic hepatectomy and synthesize the data reported in the literature.

methodsThe PubMed, Scopus, Embase, Web of Science, and World Health Organization (WHO) Global Index Medicus databases were searched from database inception to May 26th, 2022. Studies that reported outcomes after oncologic hepatectomy in LMIC settings were eligible for inclusion. Two independent reviewers performed record screening and data extraction. Risk of bias assessment was performed using the National Institutes of Health Study Quality Assessment tools. Pooled results with 95% confidence intervals (95% CIs) were calculated using a random effects model.

resultsOne hundred and thirty-five studies and 16 985 patients were included. Most studies were of a "fair" quality. Two studies described pediatric patients. Only one study was from a low-income country and most African regions were not represented. The rates of major and minor complications were 11% and 27%, respectively, while 30- and 90-day mortality rates were 2% and 3% each. Postoperative liver failure (8%), surgical site infections (6%), and bile leaks (6%) were common complications.

conclusionsThis review indicates a dearth of data from LMICs on outcomes after hepatectomy, particularly from African regions and low-income countries.

Indexed as

Developing CountriesHepatectomyLiver NeoplasmsPostoperative ComplicationsHumansliver neoplasmsliver resectionLMICsperioperative carepostoperative outcomes

Identifiers

PMID39573859
PMCPMC12120391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.