Evidence map›Paper›PMID 39572974›Full record

ArticleImmunology2025

IRF5 Controls Plasma Cell Generation and Antibody Production via Distinct Mechanisms Depending on the Antigenic Trigger.

Bharati Matta, Jenna Battaglia, Margaret Lapan, Vinay Sharma, Betsy J Barnes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The role of IRF5 as an immune regulator.Biochemical Society transactions · 2026
    Review
  2. [Endogenous neddylation in B cells regulates immune responses in mice].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bharati MattaCenter for Autoimmune Musculoskeletal and Hematopoietic Disease, The Feinstein Institutes for Medical Research, Manhasset, New York, USA.
Jenna BattagliaCenter for Autoimmune Musculoskeletal and Hematopoietic Disease, The Feinstein Institutes for Medical Research, Manhasset, New York, USA.
Margaret LapanCenter for Autoimmune Musculoskeletal and Hematopoietic Disease, The Feinstein Institutes for Medical Research, Manhasset, New York, USA.
Vinay SharmaAmity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India.
Betsy J BarnesCenter for Autoimmune Musculoskeletal and Hematopoietic Disease, The Feinstein Institutes for Medical Research, Manhasset, New York, USA.ORCID 0000-0001-6766-4352

Funding

IRF5 and Macrophage Activation Syndrome in systemic Juvenile Idiopathic ArthritisR01AR076242 · NIAMS · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BARNES, BETSY J, HAMERMAN, JESSICA A · 2019 to 2023
$3.3M
Implications for Speckled proteins 110 and 140 in adaptive immunityR03TR004623 · NCATS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI BARNES, BETSY J · 2023 to 2023
$168k
Congressionally Directed Medical Research ProgramsLupus Research Alliance W81XWH-18-1-0674NCATS NIH HHS R03 TR004623NIAMS NIH HHS R01 AR076242NIH HHS R01AR076242NIH HHS R03TR004623
6 · The paper itself

Abstract

Elevated levels of serum autoantibodies are a hallmark of systemic lupus erythematosus (SLE) and are produced by plasma cells in response to a variety of antigenic triggers. In SLE, the triggers are complex and may include both T cell-dependent/-independent and TLR-dependent/-independent mechanisms of immune activation, which ultimately contributes to the significant immune dysregulation seen in patients at the level of cytokine production and cellular activation (B cells, T cells, dendritic cells, neutrophils and macrophages). Interferon regulatory factor 5 (IRF5) has been identified as an autoimmune susceptibility gene and polymorphisms in IRF5 associate with altered expression and hyper-activation in distinct SLE immune cell subsets. To gain further insight into the mechanisms that drive IRF5-mediated SLE immune activation, we characterised wild-type (WT) and Irf5

Indexed as

Interferon Regulatory FactorsLupus Erythematosus, SystemicMice, Inbred BALB CMice, KnockoutPlasma CellsToll-Like Receptor 9AnimalsAntibody FormationB-LymphocytesLymphocyte ActivationMiceSignal TransductionInterferon Regulatory FactorsIrf5 protein, mouseTlr9 protein, mouseToll-Like Receptor 9

Identifiers

PMID39572974
PMCPMC11999051

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.