Evidence map›Paper›PMID 39572786›Full record

ArticleNature biomedical engineering2025

Solvent-mediated analgesia via the suppression of water permeation through TRPV1 ion channels.

Yuxia Liu, Yuanyuan He, Jiahuan Tong, Shengyang Guo, Xinyu Zhang, Zichao Luo, Linlin Sun, Chao Chang, Bilin Zhuang, Xiaogang Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The therapeutic potential of circular RNAs.Nature reviews. Genetics · 2025
    Review
  5. Review
  6. Advances in Terahertz Biophysics and Chemistry.Research (Washington, D.C.) · 2025
    Review
  7. Expanded toolkits for RNA circularization.Nature biomedical engineering · 2025
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuxia Liu *Department of Chemistry, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0003-1736-9253
Yuanyuan He *School of Physics, Peking University, Beijing, China.
Jiahuan Tong *Yale-NUS College, National University of Singapore, Singapore, Singapore.
Shengyang GuoDepartment of Neurobiology, School of Basic Medicine, Peking University, Beijing, China.
Xinyu ZhangDepartment of Neurobiology, School of Basic Medicine, Peking University, Beijing, China.
Zichao LuoDepartment of Chemistry, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-9236-9160
Linlin SunDepartment of Neurobiology, School of Basic Medicine, Peking University, Beijing, China.
Chao ChangSchool of Physics, Peking University, Beijing, China. gwyzlzssb@pku.edu.cn.ORCID http://orcid.org/0000-0002-4081-1583
Bilin ZhuangYale-NUS College, National University of Singapore, Singapore, Singapore. bzhuang@g.hmc.edu.ORCID http://orcid.org/0000-0003-2934-4264
Xiaogang LiuDepartment of Chemistry, National University of Singapore, Singapore, Singapore. chmlx@nus.edu.sg.ORCID http://orcid.org/0000-0003-2517-5790

Funding

National Research Foundation Singapore (National Research Foundation-Prime Minister's office, Republic of Singapore) NRF-NRFI052019-0003
6 · The paper itself

Abstract

Activation of the ion channel transient receptor potential vanilloid 1 (TRPV1), which is integral to pain perception, leads to an expansion of channel width, facilitating the passage of cations and large organic molecules. However, the permeability of TRPV1 channels to water remains uncertain, owing to a lack of suitable tools to study water dynamics. Here, using upconversion nanophosphors to discriminate between H

Indexed as

AnalgesiaSolventsTRPV Cation ChannelsWaterAnimalsDeuterium OxideHEK293 CellsHumansMaleMiceMice, Inbred C57BLMolecular Dynamics SimulationPainPermeabilityDeuterium OxideSolventsTRPV1 protein, mouseTRPV Cation ChannelsWater

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.