ArticleCommunications medicine2024
A retrospective two-center cohort study of the bidirectional relationship between depression and tinnitus-related distress.
Article in Communications medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Analysis of Depression and Anxiety in Patients With Tinnitus: A Focus on Specific Age Groups and Sex-Related Differences.Depression and anxiety · 2026Article
- Article
- Digital Tinnitus Counseling in Clinical Practice: A Multicenter Randomized Controlled Trial.Audiology research · 2025Article
- Development and comparison of machine learning models for predicting moderate-to-severe tinnitus in patients with hearing loss.Frontiers in neurology · 2025Article
- A retrospective two-center cohort study of the bidirectional relationship between depression and tinnitus-related distress.Communications medicine · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundTinnitus can cause considerable psychological distress among patients, particularly if comorbidities occur. Despite a strong relationship between tinnitus-related distress and depression, the underlying mechanisms represent a long-standing question. By investigating the co-development of tinnitus-related distress and depressiveness throughout therapy, we capture the dynamic interplay of both conditions and uncover underlying common features mediating their link.
methodsLarge datasets from two different day clinics in Germany have been analyzed using a regularization method for predictor selection (analysis 1) and latent growth curve modeling (LCM; analysis 2). Tinnitus-related distress was assessed using the Tinnitus Questionnaire (TQ). All patients have been experiencing chronic subjective tinnitus with a minimum mean severity level of TQ grade 2. Treatment at both day clinics involved tinnitus management according to clinical guidelines with minor idiosyncratic differences. Analysis 1 was performed on a dataset of 500 patients who received the Jena Interdisciplinary Treatment for Tinnitus (JITT) for 5 consecutive days between 2013 and 2017. Analysis 2 was performed on a second dataset, which included 1016 patients treated at the Tinnitus Center of the Charité Universitätsmedizin Berlin for 7 days between 2011 and 2015.
resultsHere, we show a substantial bidirectional relationship between tinnitus-related distress and depression severity while emphasizing the role of somatic symptoms and perceived stress in the experience and maintenance of tinnitus awareness. The LCM provides adequate model fit (CFI = 0.993, SRMR = 0.016).
conclusionsOur results indicate enhanced therapy success in depression when tinnitus-related distress is addressed and vice versa. The combined treatment of tinnitus and depression is proposed for future treatment strategies.
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