Evidence map›Paper›PMID 39572762›Full record

ReviewBritish journal of cancer2025

Adaptive Universal Principles for Real-world Observational Studies (AUPROS): an approach to designing real-world observational studies for clinical, epidemiologic, and precision oncology research.

Samir H Barghout, Nicholas Meti, Simren Chotai, Christina J H Kim, Devalben Patel, M Catherine Brown, Katrina Hueniken, Luna J Zhan, Stavroula Raptis, Faisal Al-Agha and 12 more

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04151342 recruitingnot on this map

CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)

TypeobservationalSponsorUniversity Health Network, TorontoRan2020 to 2029Enrolled5,500ConditionsCancer, Malignancies Multiple, Malignant Solid Tumor, Cancer, Therapy-RelatedArmsCancer treatment with tyrosine kinase inhibitors (TKIs) or other molecularly targeted therapeutic agents., Patient-reported outcomes (PROs)
NCT07737782 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Retrospective Observational Study in a Cohort of Postmenopausal Women With Genitourinary Syndrome of Menopause (GSM): Characterization of Symptoms and Impact on Quality of Life.

TypeobservationalSponsorMucosa Innovations, S.L.Ran2026 to 2026Enrolled100ConditionsVulvar Atrophy, Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause (GSM), Quality of Life
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Samir H BarghoutPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-5537-3419
Nicholas MetiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Simren ChotaiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Christina J H KimPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Devalben PatelPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
M Catherine BrownPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Katrina HuenikenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Luna J ZhanPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Stavroula RaptisApplied Health Research Centre, Unity Health, Toronto, ON, Canada.
Faisal Al-AghaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Christopher DeutschmanPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Benjamin GrantPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Martha PienkowskiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Patrick MoriartyTakeda Canada Inc., Toronto, ON, Canada.
John de AlmeidaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
David P GoldsteinPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Scott V BratmanPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-8610-4908
Frances A ShepherdPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Ming S TsaoPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-9160-5405
Andrew N FreedmanEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA.
Wei XuPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Geoffrey LiuPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Geoffrey.Liu@uhn.ca.ORCID http://orcid.org/0000-0002-2603-7296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The field of precision oncology has witnessed several advances that stimulated the development of new clinical trial designs and the emergence of real-world data (RWD) as an important resource for evidence generation in healthcare decision-making. Here, we highlight our experience with an innovative approach to a set of Adaptive, Universal Principles for Real-world Observational Studies (AUPROS). To demonstrate the utility of these principles, we used a mixed-methods approach to assess three studies that follow AUPROS at Princess Margaret Cancer Centre: (1) Molecular Epidemiology of ThorAcic Lesions (METAL), (2) Translational Head And NecK Study (THANKS), and (3) CAnadian CAncers With Rare Molecular Alterations (CARMA; NCT04151342). We performed resource assessments, stakeholder-directed surveys and discussions, analysis of funding, research output, collaborations, and a Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis. Based on these analyses, AUPROS is an approach that is applicable to a wide range of observational study designs. The universality of AUPROS allows for multi-purpose analyses of various RWD, and the adaptive nature creates opportunities for multi-source funding and collaborations. Following AUPROS can offer cost and logistical benefits and may lead to increased research productivity. Several challenges were identified pertinent to ethics approvals, sustainability, complex coordination, and data quality that require local adaptation of these principles.

Indexed as

Medical OncologyNeoplasmsObservational Studies as TopicPrecision MedicineResearch DesignHumans

Identifiers

PMID39572762
PMCPMC11746990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.