ArticleJournal of perinatology : official journal of the California Perinatal Association2025
Post-procedure pain in preterm neonates undergoing retinopathy of prematurity (ROP) screening: a prospective cohort study.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Population-Based Cohort Study for Development of National Retinopathy of Prematurity Screening Criteria.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Evidence summary for pain management during retinopathy of prematurity screening.Frontiers in pediatrics · 2025Review
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Authors and funding
9 authors.
Funding
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Abstract
objectiveTo evaluate the pain intensity in preterm infants during 48 h post retinopathy of prematurity (ROP) screening by binocular fundoscopy.
designProspective cohort study. SETTINGS: Level-III-NICU in India.
participants83 Neonates undergoing first ROP screening.
main outcome measuresPain assessment using the premature infant pain profile-revised (PIPP-R) score at baseline and 5 min, 30 min, 6 h, 24 h, and 48 h post-procedure.
resultsThe mean gestation and birth weight was 29.8 (2.3) weeks and 1256 (344)g respectively. The median (IQR) PIPP-R score at baseline was 0 which significantly increased to 10.5 (8,12.5) 5 min (immediately) after the procedure. At 30 min and 6 h, scores were 7 (5,8) and 4.5 (3,5.5) respectively. After 24 h and 48 h, it decreased to 3 (0,5) and 0 (0,4.5) respectively. Nearly 59% (95%CI:40%-83%) of neonates had severe pain (PIPP-R score > 12) immediately after procedure.
conclusionA majority of neonates experience severe pain immediately after ROP screening, and mild-moderate pain continues for 6 h. Hence, an additional pharmacological agent should be considered for reducing neonatal pain.
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